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Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II
Sponsor: Maastricht University Medical Center
Summary
After severe traumatic brain injury, adequate blood flow to the brain is essential for recovery. This depends on arterial blood pressure, yet intensive care units apply fixed targets to all patients - treating every brain and patient the same. This study aims to change that. With new technology, 'optimal' blood pressure can be determined for each individual brain and treatment can be tailored accordingly. This personalized approach to neurocritical care has never been tested in a randomized controlled study before. If effective in showing reduced brain damage biomarkers, it will fundamentally transform brain injury treatment and dramatically improve recovery outcomes for patients worldwide.
Official title: CPPopt Guided Therapy: Assessment of Target Effectiveness - II
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-05-01
Completion Date
2028-05-15
Last Updated
2026-01-06
Healthy Volunteers
No
Conditions
Interventions
Optimal cerebral perfusion pressure
The intervention group will receive CPPopt guided management with updated CPPopt targets every 4 hours. All other parameters will be handled according to Brain Trauma Foundation (BTF) guidelines.
Locations (4)
Medisch Spectrum Twente
Enschede, Netherlands
Maastricht Universitair Medisch Centrum+
Maastricht, Netherlands
Radboud University Medical Center
Nijmegen, Netherlands
Haaglanden Medisch Centrum
The Hague, Netherlands