Clinical Research Directory
Browse clinical research sites, groups, and studies.
Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II
Sponsor: Maastricht University Medical Center
Summary
After severe traumatic brain injury, adequate blood flow to the brain is essential for recovery. This depends on arterial blood pressure, yet intensive care units apply fixed targets to all patients - treating every brain and patient the same. This study aims to change that. With new technology, 'optimal' blood pressure can be determined for each individual brain and treatment can be tailored accordingly. This personalized approach to neurocritical care has never been tested in a randomized controlled study before. If effective in showing reduced brain damage biomarkers, it will fundamentally transform brain injury treatment and dramatically improve recovery outcomes for patients worldwide.
Official title: CPPopt Guided Therapy: Assessment of Target Effectiveness - II
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
62
Start Date
2027-01-01
Completion Date
2029-05-15
Last Updated
2026-09-28
Healthy Volunteers
No
Conditions
Interventions
Optimal cerebral perfusion pressure
The CPPopt treatment group will receive management according to the Brain Trauma Foundation (BTF) guidelines, except for the targeted cerebral perfusion pressure. Here, the calculated "optimal cerebral perfusion pressure (CPPopt)" will be targeted, with updated CPPopt targets every 4 hours. CPPopt treatment will be performed for a maximum of 5 days. If a patient still requires ICP treatment after 5 days, the standard, guideline-based treatment will be followed. CPPopt treatment can be shorter than 5 days, if ICP measurement is no longer required, if a patients wakes up, or if a patient dies.
Locations (4)
Medisch Spectrum Twente
Enschede, Netherlands
Maastricht Universitair Medisch Centrum+
Maastricht, Netherlands
Radboud University Medical Center
Nijmegen, Netherlands
Haaglanden Medisch Centrum
The Hague, Netherlands