Clinical Research Directory

Soft Tissue Response and IL-1β Levels Around CAD/CAM-Milled vs 3D-Printed PMMA Healing Abutments

Sponsor: Ali Hassan Eid Toto

Summary

This study looked at how the gums and tissues around dental implants heal when using two different types of temporary healing caps made of PMMA (a common dental material). These healing caps help shape the gums before placing the final crown. There are two ways to make these caps: 1. CAD/CAM-milled (carved from a solid block) 2. 3D-printed (built layer by layer using resin) The goal was to find out which type leads to healthier gum tissue. What the Researchers Did * 22 dental implants in 22 patients were included. * Each implant received one healing cap-either milled or 3D-printed. * Patients were checked after 1 week, 2 weeks, and 4 weeks. * The team measured: * Gum inflammation * Bleeding around the implant * Plaque buildup * Pocket depth around the implant * Levels of an inflammatory marker called Interleukin-1β (IL-1β) in the gum fluid (higher levels mean more inflammation). * Surface smoothness and material quality of each type of healing cap. What the Study Found * Gum inflammation and bleeding were higher with 3D-printed caps, especially at week 4. * IL-1β levels were much higher around 3D-printed caps-showing more inflammation. * Both types had some increase in plaque and probing depth over time, but there was no major difference between groups. * The milled caps had smoother surfaces and better material quality, which may have helped reduce irritation and inflammation. * 3D-printed caps were rougher and had lower polymerization (more leftover monomers), which may trigger soft-tissue irritation. What This Means * CAD/CAM-milled PMMA healing caps appear to be safer and healthier for gum healing around dental implants. * They may help reduce early inflammation, support better tissue health, and more predictably shape the gums during healing. Why This Matters for Patients * Using a smoother, better-finished healing cap may lower the risk of early gum inflammation. * Healthier soft tissue around an implant leads to better long-term implant stability. * This information can help dentists choose the best healing cap for optimal healing. Study Timeframe • The follow-up was 4 weeks, so results focus on early healing. More research is needed to know long-term differences.

Official title: Clinical and Biochemical Assessment of the Soft Tissue Response to Printed Versus Milled Polymethyl Methacrylate Custom Healing Abutments

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