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Effects of Sevoflurane vs Desflurane on Early Recovery and Cognitive Function in Elderly Patients Undergoing Scheduled Non-Cardiac Surgery
Sponsor: Hopital Charles Nicolle
Summary
The goal of this clinical study is to compare the effects of desflurane versus sevoflurane on early postoperative recovery and cognitive function in elderly patients (aged 60 years and older, ASA I-III) undergoing elective non-cardiac surgery under general anesthesia. The main questions this study aims to answer are: Which anesthetic agent allows faster emergence from anesthesia (eye opening, response to commands, extubation)? Does desflurane lead to earlier cognitive recovery as measured by the Short Orientation Memory Concentration Test (SOMCT)? Does the choice of volatile anesthetic influence the time required to achieve a modified Aldrete score (MAS) ≥ 9 and PACU discharge readiness? Researchers compared the desflurane group to the sevoflurane group to determine whether desflurane provides a superior recovery profile and minimizes delayed emergence in elderly surgical patients. Participants will: Be randomly assigned to receive either desflurane or sevoflurane for maintenance of general anesthesia. Undergo standardized induction with fentanyl, propofol, and cisatracurium, along with uniform ventilatory and monitoring protocols. Have emergence parameters recorded immediately after discontinuation of the inhaled agent (eye opening, command following, extubation). Be evaluated in the post-anesthesia care unit using the modified Aldrete Score (MAS) and SOMCT, with predefined thresholds for recovery (MAS ≥ 9, SOMCT ≥ 20). This study aims to determine whether desflurane-due to its lower blood/gas partition coefficient-offers measurable clinical benefits in terms of rapid awakening, cognitive recovery, and overall early postoperative recovery in the geriatric population.
Official title: A COMPARATIVE STUDY OF DESFLURANE VERSUS SEVOFLURANE IN ELDERLY PATIENTS: EFFECT ON EARLY RECOVERY
Key Details
Gender
All
Age Range
60 Years - Any
Study Type
INTERVENTIONAL
Enrollment
81
Start Date
2024-09-15
Completion Date
2025-04-15
Last Updated
2026-08-06
Healthy Volunteers
Yes
Interventions
Sevoflurane
Sevoflurane used for anesthesia maintenance with a MAC of 2-3% and FGF of less than 1 L/min.
Desflurane
Desflurane used for anesthesia maintenance with a MAC of 4-6% and FGF of less than 0.5 L/min.
Locations (1)
Hospital of Charles Nicolle, Tunis, Tunis 1006
Tunis, Tunis Governorate, Tunisia