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Pain Perception and Exercise-Induced Hypoalgesia Across Circadian Rhythms
Sponsor: Medipol University
Summary
The goal of this randomized crossover clinical trial is to investigate whether exercise-induced hypoalgesia (EIH) is influenced by circadian rhythm in healthy adults aged 18-40 years. The main questions it aims to answer are: * Does the time of day (morning vs. evening) influence changes in pain perception following exercise? * Do chronotype, sex, or stimulation site (bony vs. muscular) alter the magnitude of this effect? Participants will: * Complete questionnaires * Undergo quantitative sensory testing * Attend both morning and evening sessions in randomized crossover order
Official title: Exploring Pain Perception Through Exercise-Induced Hypoalgesia Across Circadian Rhythms for Healthy Participants
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
56
Start Date
2026-01
Completion Date
2026-04
Last Updated
2025-12-18
Healthy Volunteers
Yes
Conditions
Interventions
High-Intensity Functional Training (HIFT)
A 12-minute, instructor-led HIFT protocol delivered via the same video to all participants. After a 5-minute warm-up, participants perform six exercises targeting major muscle groups. The exercises are 4 lunges followed by one push-up, 10 high knees followed by 10 shuffles, burpees, squat jumps, skaters, and plank up-downs. Each exercise is done for 40 seconds then 20 seconds rest. The cycle repeats twice for a total of 12 minutes. Rate of Perceived Exertion (Borg scale) is recorded at baseline, post-warmup, during each rest interval, and immediately post-exercise. A physiotherapist supervises performance, ensures correct technique, and enforces safety and target intensity while motivating and encouraging the participant.
Supervised Deep Breathing
A 12-minute deep breathing session delivered via a prerecorded audio and supervised by a physiotherapist. The breathing rhythm includes inhaling for 4 seconds and exhaling for 6 seconds for a total 1 minute, followed by 1 minute of normal breathing. This cycle is repeated six times for a total duration of 12 minutes. Participants lie supine in a comfortable position and wear headphones. A self-reported Rate of Perceived Relaxation (RPR, 0-10) is recorded before and after. This serves as a non-exercise control to account for relaxation and attention effects.
Locations (1)
Istanbul Medipol University
Istanbul, Beykoz, Turkey (Türkiye)