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NCT07291193

Impact of Sex Hormones on Human Skin Immunity in Health and Hidradenitis Suppurativa (SIAP)

Sponsor: Institut Pasteur

View on ClinicalTrials.gov

Summary

Sex hormones are major regulators of skin immunity. Pregnancy represents a unique physiological state of profound hormonal remodeling. In late pregnancy, maternal levels of estrogens, progesterone, and other hormones increase dramatically, offering an unparalleled model to study the impact of sex hormones on skin immunity. Hidradenitis suppurativa (HS) provides a clinically relevant model to examine how sex hormones modulate skin inflammation.

Official title: Impact of Sex Hormones on Human Skin Immunity in Health and Hidradenitis Suppurativa

Key Details

Gender

All

Age Range

18 Years - 45 Years

Study Type

OBSERVATIONAL

Enrollment

240

Start Date

2026-01

Completion Date

2031-03

Last Updated

2026-01-09

Healthy Volunteers

Yes

Conditions

Interventions

PROCEDURE

Blood sample, skin microbiota and biopsy

Blood sample (maximum 40mL) Skin microbiota (collection of cells from the skin surface using a swab (non-invasive) Skin biopsy, in hormone-dependent areas and/or in a non-hormone-dependent areas