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Hyaluronic Acid With Connective Tissue Grafting for Gingival Recession
Sponsor: Saglik Bilimleri Universitesi
Summary
This study evaluates whether adding 0.8% hyaluronic acid (HA) to connective tissue grafting and coronally advanced flap surgery improves clinical and esthetic outcomes in the treatment of gingival recession. Adult patients with Miller I-II or Cairo RT1 recession defects will be randomly assigned to receive CTG alone or CTG with adjunctive HA. Mean root coverage at 6 months is the primary outcome, while secondary measures include gingival thickness, clinical attachment level, esthetic scores, postoperative morbidity, and quality of life. The study aims to determine whether HA enhances soft tissue healing and root coverage predictability compared with conventional CTG.
Official title: Clinical and Aesthetic Evaluation of Hyaluronic Acid in Addition to Connective Tissue Grafts in the Treatment of Gingival Recession Defects
Key Details
Gender
All
Age Range
18 Months - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-07-01
Completion Date
2026-07-01
Last Updated
2025-12-23
Healthy Volunteers
No
Conditions
Interventions
Hyaluronic Acid (0.8%) - Applied over CTG before flap closure (Test group only).
A 0.8% hyaluronic acid (HA) gel is applied to the connective tissue graft (CTG) before flap closure during the coronally advanced flap (CAF) procedure. The HA gel is used as an adjunctive biologic material to potentially enhance wound healing, soft tissue thickness, esthetic outcomes, and overall root coverage performance
Connective Tissue Graft + Coronally Advanced Flap (CTG + CAF)
A standardized coronally advanced flap (CAF) procedure combined with a subepithelial connective tissue graft (CTG) is performed to treat gingival recession defects. The surgical protocol includes flap elevation, graft harvesting and placement, and flap advancement and suturing.
Locations (1)
University of Health Sciences, Gülhane Faculty of Dentistry
Ankara, None Selected, Turkey (Türkiye)