Clinical Research Directory

Inclusion Criteria: * Subjects sign informed consent voluntarily. * Male or female aged 18 to 45 years. * Body weight ≥ 50.0kg for male and ≥ 45.0kg for female, and body mass index (BMI) between 18.5 and 26.0 kg/m2. Exclusion Criteria: * Subjects have any clinically significant medical condition or chronic disease. * Subjects experienced a history of keratopathy, fundus disease, increased intraocular pressure, or angle-closure glaucoma. Subjects have any abnormal and clinically significant test for ophthalmic examination during screening. * Subjects with a history of orthostatic hypotension or syncope. * Subjects with condition that may interfere with the drug absorption, distribution, metabolism and excretion significantly. * Subjects had a history of surgery within 3 months prior to administration, or had not recovered, or have a surgical plan during the study. * Subjects have any clinically significant abnormal vital signs, laboratory values, and ECGs. * Subjects have used any of nonprescription drugs within 7 days or prescription drugs within 28 days prior to first dosing. * Subjects have a history of allergic diseases, or allergic to any substance contained in the formulation. * Subjects have a positive test for HBsAg, HCV-Ab, HIV-Ab, or syphilis antibody.