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Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial
Sponsor: Amgen
Summary
The primary objective of this trial is to evaluate the effect of olpasiran, compared to placebo, on non-calcified plaque (NCP) volume as measured by Coronary Computed Tomography Angiography (CCTA).
Official title: A Double-blind, Randomized, Placebo-controlled, Multi-center Study Evaluating the Safety, Tolerability, and Effect of Olpasiran on Coronary Artery Plaque Burden Assessed by Coronary Computed Tomography Angiography in Participants With Stable Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a)
Key Details
Gender
All
Age Range
35 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
406
Start Date
2026-03-23
Completion Date
2028-06-15
Last Updated
2026-04-16
Healthy Volunteers
No
Conditions
Interventions
Olpasiran
Olpasiran will be administered SC.
Placebo
Placebo will be administered SC.
Locations (40)
Bridgeport Hospital
Bridgeport, Connecticut, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
Midwest Heart and Vascular Specialists
Overland Park, Kansas, United States
Flourish Bowie
Bowie, Maryland, United States
Montefiore Medical Center - Bronx
Philadelphia, Pennsylvania, United States
Vital Heart and Vein
Humble, Texas, United States
Advara HeartCare Wesley
Auchenflower, Queensland, Australia
University of The Sunshine Coast Clinical Trials, Sippy Downs
Sippy Downs, Queensland, Australia
Advara HeartCare Leabrook
Leabrook, South Australia, Australia
North York Diagnostic and Cardiac Centre
Vaughan, Ontario, Canada
Peking University First Hospital
Beijing, Beijing Municipality, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
The Second Xiangya Hospital of Central South University
Changsha, Hunan, China
The Third Xiangya Hospital of Central South University
Changsha, Hunan, China
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China
Shaanxi Provincial Peoples Hospital
Xi'an, Shaanxi, China
Jinan Central Hospital
Jinan, Shandong, China
Regionshospitalet Gødstrup
Herning, Denmark
Regionshospitalet Viborg
Viborg, Denmark
Centre Hospitalier Universitaire de Nice - Hopital Pasteur
Nice, France
Centre Hospitalier Universitaire de Bordeaux Hopital Haut-Leveque
Pessac, France
Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil
Toulouse, France
Centre Hospitalier Regional Universitaire de Tours - Hopital Trousseau
Tours, France
Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin
Berlin, Germany
Universitaetsklinikum Essen
Essen, Germany
Universitaetsklinikum Frankfurt
Frankfurt am Main, Germany
Klinikum rechts der Isar der TUM
München, Germany
Azienda Ospedaliera Universitaria di Ferrara Arcispedale Sant Anna
Ferrara, Italy
IRCCS Centro Cardiologico Monzino
Milan, Italy
IRCCS Policlinico San Donato
San Donato Milanese, Italy
Azienda Ospedaliera Ordine Mauriziano di Torino
Torino, Italy
Tomakomai City Hospital
Tomakomai-shi, Hokkaido, Japan
Osaka Keisatsu Hospital
Osaka, Osaka, Japan
University of Yamanashi Hospital
Chuo-shi, Yamanashi, Japan
Tergooiziekenhuizen, locatie Hilversum
Hilversum, Netherlands
Hospital Universitario Virgen Macarena
Seville, Andalusia, Spain
Hospital Alvaro Cunqueiro
Vigo, Galicia, Spain
Hospital Universitari i Politecnic La Fe
Valencia, Valencia, Spain
Hospital Universitario Ramon y Cajal
Madrid, Spain