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PREcision MEDicine In Achalasia (PREMEDIA) - Cohort
Sponsor: Northwestern University
Summary
The goal of this observational study is to learn about how the doctor decides how long to cut t the esophageal muscle during Per-Oral Endoscopic Myotomy (POEM) in patients with difficulty swallowing due to certain conditions. The main question it aims to answer is: does pre-POEM testing help the physician choose how long to cut the muscle. Participants will allow researchers to access their standard of care information in their medical record, complete questionnaires at up to 6 times over a 2-year period.
Official title: PREcision MEDicine In Achalasia - A Multicenter Randomized Non-Inferiority Clinical Trial of Short Tailored POEM vs. Standard POEM for Non-Spastic Achalasia and A Multicenter Prospective Cohort Study of Long Tailored POEM for Spastic Esophageal Motility Disorders
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2026-04-01
Completion Date
2030-03-01
Last Updated
2025-12-19
Healthy Volunteers
No
Conditions
Locations (13)
Mayo Clinic Arizona
Scottsdale, Arizona, United States
University of California San Diego
La Jolla, California, United States
University of Colorado Denver
Denver, Colorado, United States
University of Florida
Gainesville, Florida, United States
Adventist Health System/Sunbelt, Inc
Orlando, Florida, United States
Emory University
Atlanta, Georgia, United States
Northwestern University
Chicago, Illinois, United States
Johns Hopkins University
Baltimore, Maryland, United States
Washington University
St Louis, Missouri, United States
Weill Cornell Medical College
New York, New York, United States
Case Western Reserve University
Cleveland, Ohio, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Baylor Scott & White Health
Dallas, Texas, United States