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Menthol for Improving Movement and Sleep in Parkinson's Disease Patients
Sponsor: Taipei Medical University Hospital
Summary
Parkinson's disease (PD) is a progressive neurological disorder characterized by both motor and non-motor symptoms due to the degeneration of dopamine-producing neurons. There is currently no cure. Menthol, a natural compound that activates TRPM8 receptors, has shown neuroprotective and motor function benefits in preclinical PD models. In mice, distal limb immersion in menthol improved dopamine neuron survival and motor performance. Similar menthol-based interventions improved outcomes in a stroke model and a clinical trial with stroke patients. This study investigates whether topical menthol can offer therapeutic benefits for individuals with PD.
Official title: Effect of Menthol on Motor Deficits and Sleep Disturbances in Patients With Parkinson's Disease
Key Details
Gender
All
Age Range
30 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2025-12-15
Completion Date
2027-07-31
Last Updated
2026-01-08
Healthy Volunteers
No
Conditions
Interventions
Menthol gloves and socks
Participants will wear menthol-containing gloves and socks for five minutes per day, five days a week, over a four-week period.
Placebo gloves and socks
Participants will wear gloves and socks with plain lotion for five minutes per day, five days a week, over a four-week period.
Locations (1)
Taipei Medical University Hospital
Taipei, Taiwan