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NOT YET RECRUITING
NCT07294469
PHASE2

Menthol for Improving Movement and Sleep in Parkinson's Disease Patients

Sponsor: Taipei Medical University Hospital

View on ClinicalTrials.gov

Summary

Parkinson's disease (PD) is a progressive neurological disorder characterized by both motor and non-motor symptoms due to the degeneration of dopamine-producing neurons. There is currently no cure. Menthol, a natural compound that activates TRPM8 receptors, has shown neuroprotective and motor function benefits in preclinical PD models. In mice, distal limb immersion in menthol improved dopamine neuron survival and motor performance. Similar menthol-based interventions improved outcomes in a stroke model and a clinical trial with stroke patients. This study investigates whether topical menthol can offer therapeutic benefits for individuals with PD.

Official title: Effect of Menthol on Motor Deficits and Sleep Disturbances in Patients With Parkinson's Disease

Key Details

Gender

All

Age Range

30 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

80

Start Date

2025-12-15

Completion Date

2027-07-31

Last Updated

2026-01-08

Healthy Volunteers

No

Interventions

DRUG

Menthol gloves and socks

Participants will wear menthol-containing gloves and socks for five minutes per day, five days a week, over a four-week period.

DRUG

Placebo gloves and socks

Participants will wear gloves and socks with plain lotion for five minutes per day, five days a week, over a four-week period.

Locations (1)

Taipei Medical University Hospital

Taipei, Taiwan