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Impact of Lifestyle Interventions on Cognitive Decline in Non-alcoholic Fatty Liver Disease
Sponsor: Khyber Medical University Peshawar
Summary
This study investigates whether a structured lifestyle program can help improve thinking skills and liver health in adults with Non-Alcoholic Fatty Liver Disease (NAFLD). We are enrolling 45 participants, aged 18-42, who will be randomly assigned to one of three groups for six months: one receiving general health advice, a second following a supervised Mediterranean diet plan, and a third combining the same diet with a regular walking program. The main goal is to see if these diet and exercise interventions can lead to better scores on memory and reasoning tests, reduce liver stiffness measured by a painless scan (FibroScan), and improve related blood markers of inflammation and hormone balance.
Official title: Impact of Lifestyle Interventions on Cognitive Decline in NAFLD: A Randomized Controlled Trial of Liver Fibrosis, Hormonal Imbalance, and Inflammatory Markers
Key Details
Gender
All
Age Range
18 Years - 42 Years
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2025-10-01
Completion Date
2026-06-15
Last Updated
2025-12-19
Healthy Volunteers
No
Interventions
Structured Mediterranean Diet
A culturally adapted, structured dietary plan based on the Mediterranean diet principles, delivered through individual dietitian counseling, provision of weekly meal plans, and ongoing compliance support (food diaries, recalls, monthly check-ins).
Control / General Advice
This intervention consists of providing standardized, non-structured verbal and written information on the principles of a balanced diet and the benefits of regular physical activity, as per routine clinical practice. It serves as the active comparator representing minimal intervention.
Locations (2)
Khyber Teaching Hospital
Peshawar, KPK, Pakistan
Northwest General Hospital
Peshawar, KPK, Pakistan