Clinical Research Directory

Inclusion Criteria: * Any age * Signed informed consent form (ICF) for participation in the study, including genetic testing * Meets the criteria for HCM HCM Criteria for Probands ≥ 18 Years Based on ECHO or CMR * End-diastolic LV wall thickness ≥ 15mm in any segment of the LV HCM Criteria for Probands ≥ 18 Years with Arterial Hypertension * 1st degree of AH: The same ECHO/CMR criteria as patients without AH * 2nd and 3rd degrees of AH: * Asymmetric LV hypertrophy: the ratio of septum / LV PW ≥ 1.5 or apical HCM * If asymmetry \< 1.5, the wall thickness must be ≥ 20mm * For all patients with arterial hypertension, the presence of at least one of the following ECG changes is obligatory: * Pathological "dagger" Q wave * T-wave inversion ≥ 3mm in ≥ 2 adjacent leads * Poor R progression / QS / RV1 \> RV2 \< RV3 in V1-V4 HCM Criteria for First-degree Relatives ≥ 18 Years Based on ECHO or CMR and ECG: * End-diastolic LV wall thickness ≥ 13mm in any segment and/or ECG changes in the absence of CAD, such as (at least one of the following): * Quantitative signs of LV hypertrophy\* + repolarization changes * T wave inversions in at least 2 adjacent leads: ≥ 3mm in V3-V6, I, aVL or ≥ 5mm in II, III, aVF * Pathological Q waves (\> 25% of R) in at least 2 adjacent leads: II, III, aVF (in the absence of left anterior hemiblock) or V1-V4, or I, aVL, V5-V6 \*Presence at least one of the following: * Sokolow-Lyon index (S in V1 + R in V5 or V6) \> 35mm * R or S in limb leads ≥ 20mm * S in V1 or V2 ≥ 30mm * R in V5 or V6 ≥ 30mm HCM Criteria for Children and Adolescents \< 18 Years * End-diastolic LV wall thickness in any segment \> 2.5 standard deviations (\> 2.5 z-score) above the norms for the index gender, age and weight (or body surface area) in asymptomatic children/adolescents without a family history of HCM * End-diastolic LV wall thickness in any segment \> 2.0 standard deviations (\> 2.0 z-score) above the norms for the index gender, age and weight (or body surface area) in children/adolescents with a family history of HCM or a positive genetic test Exclusion Criteria: * Uncontrolled arterial hypertension of 2nd - 3rd degree with mild/moderate (\&lt; 20mm) or symmetric LV hypertrophy or a "normal" ECG * Hemodynamically significant congenital or acquired valve heart disease * Established diagnosis of metabolic, infiltrative, endocrine, or other diseases known as "phenocopies of HCM"