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Circulating Tumor Cell Counts in Postoperative ENE-Positive Oral Cavity Cancer Patients After Adjuvant CCRT
Sponsor: Chang Gung Memorial Hospital
Summary
The aim 1 of this trial is the development of the Circulating tumor cells (CTCs) definition of oral cancer minimal residual disease (MRD), and aim 2 is a prospective trial of oral cancer treatment. If this trial is successful, it is expected that it may be able to provide a standard diagnostic tool (MRD in Oral Cavity Squamous Cell Carcinoma (OCSCC)) and treatment mode (extended adjuvant chemotherapy with low-dose oral chemotherapy). The survival rate of patients will be improved.
Official title: A Randomized, Prospective Phase II Clinical Trial - Extended Chemotherapy or Not Based on Circulating Tumor Cell Counts in Postoperative ENE-Positive Oral Cavity Cancer Patients After Completing Adjuvant Concurrent Chemoradiotherapy
Key Details
Gender
All
Age Range
18 Months - 90 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2025-08-01
Completion Date
2028-07-31
Last Updated
2025-12-22
Healthy Volunteers
Yes
Conditions
Interventions
low-dose oral chemotherapy
recruit 100 oral cavity cancer patients with ENE or other postoperative risks.10 mL of research blood was drawn four times in total.Each patient must continue to be tracked for ENE or other postoperative risks for one year, and with blood testing every tree month.
Locations (1)
Linkou Chang Gung Memorial Hospital
Taoyuan, Taiwan