Clinical Research Directory
Browse clinical research sites, groups, and studies.
Evaluation of the Clinical Efficacy of Antrrix Probiotics in Improving Recurrent Respiratory Infections in Infants and Young Children
Sponsor: Min-Tze LIONG
Summary
This study is an 8-weeks, randomized controlled trial involving children under 6 years of age who meet clinical diagnostic criteria for RRTI. Participants are randomized to receive either probiotic or placebo. The primary clinical outcomes assessed are duration and frequency of respiratory symptoms and quality of life. To investigate potential mechanisms, stool samples were collected pre- and post-intervention for 16S rRNA gene sequencing to analyze changes in gut microbiota composition and identify specific bacterial taxa associated with clinical improvements.
Key Details
Gender
All
Age Range
1 Day - 6 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2025-05-14
Completion Date
2026-01-31
Last Updated
2025-12-30
Healthy Volunteers
No
Conditions
Interventions
Probiotic
Daily 2 × 10 9 CFU per 6 drops containing Lactobacillus rhamnosus CRL1505+Bifidobacterium brevis M-16V strain in MCT oil
Placebo
Daily 6 drops MCT oil without probiotics
Locations (2)
Xinyi City People's Hospital
Xingyi, Guangdong, China
Universiti Sains Malaysia
George Town, Pulau Pinang, Malaysia