Clinical Research Directory
Browse clinical research sites, groups, and studies.
Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics
Sponsor: Case Western Reserve University
Summary
Periodontitis is a prevalent chronic inflammatory disease that exacerbates systemic inflammation and poses challenges for glycemic control in diabetic patients. While scaling and root planing (SRP) remains the cornerstone of periodontal therapy, adjunctive treatments such as Arestin (minocycline microspheres) have shown promise in enhancing clinical outcomes. This study aims to evaluate the impact of adding Arestin to SRP on periodontal pocket closure, glycemic control, and systemic inflammation in diabetic patients with periodontitis.
Official title: Effectiveness of Scaling and Root Planing With and Without Minocycline Microspheres (Arestin) in Improving Periodontal and Glycemic Outcomes in Diabetic Patients With Periodontitis: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
42
Start Date
2026-02-06
Completion Date
2028-06
Last Updated
2026-02-19
Healthy Volunteers
No
Conditions
Interventions
local antibiotic application of topical minocycline
Scaling and Root planing + local application of Arestin ( Minocycline microsphere)
Scaling and Root Planing
Only scaling and root planing
Locations (1)
Case Western Reserve University
Cleveland, Ohio, United States