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Study of ENV-294 in Adults With Moderate-to-Severe Atopic Dermatitis
Sponsor: Enveda Therapeutics
Summary
The goal of this clinical trial is to learn about the safety and effectiveness of ENV-294 in adults with moderate to severe atopic dermatitis. The main questions it will answer are: * Is there an impact on the severity and area of atopic dermatitis when participants take ENV-294 * What medical problems do participants have when taking ENV-294 Researchers will review the atopic dermatitis present at the beginning of the study against the atopic dermatitis present at the end of the study. Participants will: * Take drug ENV-294 or a placebo once every day for 12 weeks * Visit the clinic every 2 to 4 weeks for checkups and tests * Keep a diary of their symptoms and when they took their study drug ENV-294 * Return to the clinic for the final study visit at approximately week 16
Official title: A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 12-Week Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of ENV 294 in Adult Participants With Moderate-to-Severe Atopic Dermatitis
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
64
Start Date
2025-12-22
Completion Date
2026-12
Last Updated
2026-04-03
Healthy Volunteers
No
Conditions
Interventions
ENV-294
ENV-294 is an orally administered investigational drug supplied as capsules. Each participant will receive ENV-294 at a total dose of 800 milligrams (mg) once daily by mouth for 12 weeks. Capsules should be taken with water, approximately the same time each day, with or without food, as directed by the study physician.
Placebo
Matching oral capsule that does not contain active drug. Administered once daily by mouth for 12 weeks under the same conditions as the investigational product.
Locations (17)
Cahaba & Skin Health Center
Birmingham, Alabama, United States
Burke Pharmaceutical Research
Hot Springs, Arkansas, United States
Center for Dermatology Clinical Research
Fremont, California, United States
Dermatology Cosmetic Laser Associates of La Jolla
San Diego, California, United States
TCR Medical Corporation
San Diego, California, United States
Southern Indiana Clinical Trials
New Albany, Indiana, United States
Options Research Group
West Lafayette, Indiana, United States
Skin Sciences
Louisville, Kentucky, United States
Oakland Hills Dermatology
Auburn Hills, Michigan, United States
Michigan Center for Skin Care Research
Clinton Township, Michigan, United States
JDR Dermatology Research
Las Vegas, Nevada, United States
Apex Clinical Research Center
Canton, Ohio, United States
Best Skin Research
Camp Hill, Pennsylvania, United States
Arlington Research Center
Arlington, Texas, United States
Center for Clinical Studies
Houston, Texas, United States
Texas Dermatology and Laser Specialists
San Antonio, Texas, United States
Virginia Dermatology & Skin Cancer Center
Norfolk, Virginia, United States