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Study of ENV-294 in Adults With Moderate-to-Severe Atopic Dermatitis
Sponsor: Enveda Therapeutics
Summary
The goal of this clinical trial is to learn about the safety and effectiveness of ENV-294 in adults with moderate to severe atopic dermatitis. The main questions it will answer are: * Is there an impact on the severity and area of atopic dermatitis when participants take ENV-294 * What medical problems do participants have when taking ENV-294 Participants will: * Take drug ENV-294 or a placebo once every day for 12 weeks * Visit the clinic every 2 to 4 weeks for checkups and tests * Keep a diary of their symptoms and when they took their study drug * Return to the clinic for the final study visit at approximately week 16
Official title: A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 12-Week Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of ENV-294 in Adult Participants With Moderate-to-Severe Atopic Dermatitis
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-12-22
Completion Date
2026-12
Last Updated
2026-05-12
Healthy Volunteers
No
Conditions
Interventions
ENV-294
ENV-294 is an orally administered investigational drug supplied as tablets. Participants receive ENV-294 once daily by mouth for 12 weeks.
Placebo
Matching oral tablet that does not contain active drug. Administered once daily by mouth for 12 weeks under the same conditions as the investigational product.
Locations (20)
Enveda Investigative Site
Birmingham, Alabama, United States
Enveda Investigative Site
Hot Springs, Arkansas, United States
Enveda Investigative Site
Beverly Hills, California, United States
Enveda Investigative Site
Fremont, California, United States
Enveda Investigative Site
San Diego, California, United States
Enveda Investigative Site
San Diego, California, United States
Enveda Investigative Site
New Albany, Indiana, United States
Enveda Investigative Site
West Lafayette, Indiana, United States
Enveda Investigative Site
Louisville, Kentucky, United States
Enveda Investigative Site
Auburn Hills, Michigan, United States
Enveda Investigative Site
Bay City, Michigan, United States
Enveda Investigative Site
Clinton Township, Michigan, United States
Enveda Investigative Site
Las Vegas, Nevada, United States
Enveda Investigative Site
Canton, Ohio, United States
Enveda Investigative Site
Mayfield Heights, Ohio, United States
Enveda Investigative Site
Camp Hill, Pennsylvania, United States
Enveda Investigative Site
Arlington, Texas, United States
Enveda Investigative Site
Houston, Texas, United States
Enveda Investigative Site
San Antonio, Texas, United States
Enveda Investigative Site
Norfolk, Virginia, United States