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Food Preferences and Craniopharyngiomas
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The hypothalamus plays a key role in regulating appetite, satiety, and energy balance. When tumors such as craniopharyngiomas develop in this region, they can disrupt these mechanisms and lead to a form of severe weight gain known as hypothalamic obesity. Several factors play a role in the development of hypothalamic obesity that is often resistant to traditional treatments. Changes in food preferences notably a higher liking for food rich in fat and sugar may be implicated as has been reported in common obesity. The working hypothesis of the study is that hypothalamic lesions may alter food preferences, leading to an increased preference for high-fat and high-sugar foods, and that these changes in dietary choices contribute among other factors to the development of hypothalamic obesity. By providing the first evaluation of food preferences in adults treated surgically for craniopharyngiomas, this study will shed light on the role of hypothalamic lesions in modifying dietary choices. The results may help explain why some patients experience rapid and resistant weight gain, and could guide future strategies to better manage hypothalamic obesity.
Official title: Evaluation of Food Preferences in Patients Treated Surgically for Craniopharyngiomas
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
346
Start Date
2026-02
Completion Date
2028-12
Last Updated
2026-02-23
Healthy Volunteers
No
Conditions
Locations (1)
Department of endocrinology, diabetology and nutrition, Ambroise Paré Hospital - APHP
Boulogne-Billancourt, France