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Aortic No-Touch vs Partial Aortic Clamping in Off-Pump CABG
Sponsor: China National Center for Cardiovascular Diseases
Summary
To explore surgical strategies that reduce perioperative neurologic complications in cardiovascular surgery, with the aim of improving perioperative outcomes and quality of life while reducing the socioeconomic burden. Specifically: This multicenter, randomized controlled clinical trial will evaluate the benefits of a novel aortic no-touch technique in reducing perioperative silent brain infarction(SBI) among patients undergoing surgical treatment for coronary artery disease. The findings are expected to provide a safe and effective myocardial revascularization strategy for individuals at high risk of cerebral ischemia.
Official title: Surgical Techniques to Prevent Perioperative Neurologic Complications in Patients Undergoing Coronary Artery Bypass Grafting
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
380
Start Date
2026-02-14
Completion Date
2028-06-30
Last Updated
2026-02-19
Healthy Volunteers
No
Conditions
Interventions
Aortic no-touch coronary artery bypass grafting (RIMA-SVG)
Ascending aortic no-touch CABG with saphenous vein graft (SVG) anastomosed to the right internal mammary artery (RIMA)
Conventional off-pump CABG with partial clamping of the ascending aorta (Ao-SVG)
Off-pump CABG with proximal saphenous vein graft (SVG) anastomoses constructed on the ascending aorta using a partial-occlusion (side-biting) clamp.
Locations (4)
Fuwai Hospital Chinese Academy of Medical Sciences
Beijing, China
Peking University First Hospita
Beijing, China
Qingdao Cardiovascular Hospital
Qingdao, China
Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen
Shenzhen, China