Clinical Research Directory
Browse clinical research sites, groups, and studies.
The HER Project: HRD in EGFR-mutated NSCLC
Sponsor: IRCCS San Raffaele
Summary
This observational retrospective-prospective study aims to evaluate the prevalence of homologous recombination deficiency (HRD) in metastatic EGFR mutated NSCLC and to assess its correlation with clinical and molecular features. Based on the hypothesis that HRD identifies a distinct EGFRm subgroup with prognostic value and a potential sensitivity to PARP inhibitor-based strategies, translational analysis will be performed with multiple pre-clinical models, ranging from human cancer cells to murine models.
Official title: The HER Project: Homologous Recombination Deficiency in EGFR-Mutated NSCLC, a Retrospective and Prospective Translational Single-center Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2025-12-01
Completion Date
2032-12-31
Last Updated
2025-12-31
Healthy Volunteers
No
Interventions
No Intervention: Observational Cohort
Observational study only; participants receive standard-of-care treatments not assigned by the study
Locations (1)
Dept. Medical Oncology
Milan, MI, Italy