Clinical Research Directory

Inclusion Criteria: * Born female * Aged between 18-29 years old; * Living in Kambia district (or neighbouring district if included) without plans to move away in the next 12 months; * Willing to participate in the study and have signed the informed consent form; * In good health as determined by a medical history (a physical examination will be conducted if necessary according to the clinician's judgement); * Willing to be tested for HIV; * Are HIV negative at the screening visit; * Not pregnant; * Able to pass a Test of Understanding (TOU); * Willing to provide cervical, urine and blood samples; * Agree to be vaccinated with a single dose of Gardasil9® if randomised to the vaccine arm at Day 0; * Have no visible suspicious cervical lesions on examination. * Agree to a pregnancy test at screening and before any HPV vaccination. Exclusion Criteria: * They have been previously vaccinated against HPV; * They have a chronic condition, such as autoimmune conditions, degenerative diseases, neurologic or genetic diseases among others; * They are HIV positive or immunocompromised; * They are pregnant or planning to get pregnant in the next 12 months; * They are less than three months post-partum or currently breastfeeding; * They are allergic to one of the vaccine components or to latex; * They are sexually active and are not using, or are not willing to use, an effective birth control method from D-14 until 60 days after the last vaccine dose * The nurse or clinician determining the eligibility, in agreement with principal investigator, considers that there is a reason that precludes participation.