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NOT YET RECRUITING
NCT07303777
PHASE2

Efficacy, Safety, and PopPK Profile of ABP-745 in Patients With Atherosclerosis

Sponsor: Atom Therapeutics Co., Ltd

View on ClinicalTrials.gov

Summary

This is a multicenter, randomized, double-blind, placebo parallel controlled study to evaluate the preliminary efficacy, safety, and PopPK profile of ABP-745 in patients with ASCVD. Efficacy of ABP-745 in reducing atherosclerotic plaque compared with placebo will be evaluated in participants with ASCVD. The primary efficacy measurement will be assessed at 52W of treatment.

Official title: A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Study to Evaluate the Efficacy, Safety, and Population Pharmacokinetics (PopPK) Profile of ABP-745 in Patients With Atherosclerosis

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

200

Start Date

2026-04

Completion Date

2028-04

Last Updated

2026-04-09

Healthy Volunteers

No

Interventions

DRUG

ABP-745 Dose A

ABP-745 Dose A - tablets (PO), low dose , QD

DRUG

Placebo

ABP-745 placebo - tablets (PO), non-active,QD

DRUG

ABP-745 Dose B

ABP-745 Dose B - tablets (PO), Midum dose, QD

DRUG

ABP-745 Dose C

ABP-745 Dose C - tablets (PO), High dose, QD

Locations (33)

Cardiovascular Research Foundation of Southern California

Beverly Hills, California, United States

Cardiovascular Institute of San Diego INC

San Diego, California, United States

The Lundquist Institute

Torrance, California, United States

Washington University School of Medicine, St.louis

St Louis, Missouri, United States

NovaTrails

Newcastle, New South Wales, Australia

University of the Sunshine Coast Clinical Trials Unit - Morayfield

Morayfield, Queensland, Australia

Core Research Group Pty Ltd

Brisbane, Australia

UniSC Clinical Trials (Brisbane)

Brisbane, Australia

Cognivus

Wahroonga, Australia

Beijing Friendship Hospital, Capital Medical University

Beijing, China

Peking Union Medical College Hospital

Beijing, China

Peking University First Hospital

Beijing, China

Xuanwu Hospital Capital Medical University

Beijing, China

Dalian Second Hospital

Dalian, China

Guangdong Province Hospital

Guangzhou, China

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine

Hangzhou, China

The First Affiliated Hospital of Zhejiang University school of medicine

Hangzhou, China

Zhejiang Provincial People's Hospital

Hangzhou, China

Jinan Central Hospital

Jinan, China

Jiangsu Province Hospital

Nanjing, China

Nanjing Drum Tower Hospital

Nanjing, China

Huashan Hospital Fudan University

Shanghai, China

Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai, China

Shanghai General Hospital

Shanghai, China

The Zhongshan Hospital Affiliated to Fudan University

Shanghai, China

The First Affiliated Hospital of Soochow University

Suzhou, China

Tianjin General Hospital

Tianjin, China

Renmin Hospital of Wuhan University

Wuhan, China

Wuxi People's Hospital

Wuxi, China

Shaanxi Provincial People's Hospital

Xi'an, China

The First Affiliated Hospital of Xian Jiaotong University

Xi'an, China

The Second Affiliated Hospital of Xi'an Jiaotong University

Xi'an, China

The Affiliated Hospital of Xuzhou Medical College

Xuzhou, China