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Clinical and Genetic Aspects of Fetuses With Sex-chromosome Disorders
Sponsor: University of Aarhus
Summary
To conduct a comprehensive clinical investigation of electively aborted fetuses with sex chromosome disorders and their placentas, in parallel with analyses of epigenetic alterations and changes in gene expression in these fetuses and their placentas, with the aims to: 1. delineate how variations in sex chromosome number affect the epigenetic and genetic mechanisms regulating gene expression in the placenta and in multiple fetal tissues in fetuses with sex chromosome disorders; 2. identify the epigenetic and genetic mechanisms and placental and fetal alterations that underlie the phenotypic manifestations observed in fetuses with sex chromosome disorders.
Key Details
Gender
All
Age Range
11 Weeks - 22 Weeks
Study Type
OBSERVATIONAL
Enrollment
120
Start Date
2024-01-01
Completion Date
2029-12-31
Last Updated
2026-01-08
Healthy Volunteers
No
Conditions
Locations (1)
Aarhus University Hospital
Aarhus, Denmark