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Characterising the Network-Specific Effects of Piriform Cortex Stimulation Via SEEG
Sponsor: Xuanwu Hospital, Beijing
Summary
The prospective study aims to characterize the network-specific modulatory effects of piriform cortex stimulation in patients undergoing stereotactic EEG for drug-resistant epilepsy. Using multimodal data, it seeks to link stimulation-evoked electrophysiological responses across brain networks with clinical outcomes, to inform targeted neuromodulation therapies.
Official title: Characterising the Network-Specific Effects of Piriform Cortex Stimulation Via SEEG With Multimodal Data Integration
Key Details
Gender
All
Age Range
14 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2025-12-08
Completion Date
2027-11-08
Last Updated
2025-12-26
Healthy Volunteers
No
Conditions
Interventions
SEEG recordings and SPES
The intervention involves single-pulse electrical stimulation (SPES) applied during stereotactic electroencephalography (SEEG) monitoring. Low-intensity, standardized electrical pulses are delivered to targeted contacts within or near the piriform cortex via implanted depth electrodes, while simultaneous full-bandwidth SEEG recordings capture network-wide electrophysiological responses, allowing characterization of stimulation-evoked brain network activation and modulation patterns.
Locations (1)
Xuanwu Hospital
Beijing, Beijing Municipality, China