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EFFICACY OF MELATONIN IN MANAGEMENT OF HYPOXIC ISCHEMIC ENCEPHALOPATHY (HIE) IN NEONATES
Sponsor: University of Child Health Sciences and Children's Hospital, Lahore
Summary
To compare the survival rate and improvement in stage of hypoxic ischemic encephalopathy (HIE) at day 7 of treatment in neonates treated with versus without melatonin in addition to standard supportive therapy.
Key Details
Gender
All
Age Range
1 Hour - Any
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2025-12-10
Completion Date
2026-05-10
Last Updated
2025-12-26
Healthy Volunteers
No
Conditions
Interventions
Melatonin
55 neonates will be assigned group A in which newborns will be given single 10mg dose of melatonin through nasogastric tube in addition to standard supportive therapy.
intravenous (IV) fluids, intensive monitoring, broad-spectrum antibiotic cover
55 neonates will be assigned group B in which patients will be given standard supportive therapy only.
Locations (1)
Children Hospital and University of Child Health Sciences, Lahore
Lahore, Punjab Province, Pakistan