Clinical Research Directory

Inclusion Criteria: 1. Adult, age ≥ 18 and \< 80 years 2. Diagnosis of ischemic cholangiopathy defined as non-anastomotic biliary strictures confirmed by imaging (ERCP, MRI, percutaneous cholangiogram) 3. Cholestasis noted by elevated alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) 4. Imaging and clinical findings present at least 4 weeks after but within 12 months of liver transplantation 5. No recent hospitalization within 2 weeks before enrollment to ensure clinical stability Exclusion Criteria: 1. Decompensated liver disease, including but not limited to ascites requiring paracentesis, hepatic encephalopathy, or variceal bleeding. 2. Pregnancy or breastfeeding. 3. Current or recent (within 30 days) use of other investigational agents or fenofibrate. 4. Current or recent (within 30 days) use of cyclosporine 5. Known hypersensitivity or contraindication to seladelpar or its excipients. 6. Severe concomitant illness (renal, cardiac, or other systemic condition) that, in the investigator's judgment, would interfere with study participation or interpretation of results. 7. ALT \> 150 IU/L. 8. AST \> 150 IU/L. 9. Total bilirubin \> 5 mg/dL at screening