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ACTIVE NOT RECRUITING
NCT07305831
PHASE1

A Clinical Trial to Evaluate the Effect of Ulonivirine (MK-8507) on Heart Rhythm in Healthy Adults (MK-8507-012)

Sponsor: Merck Sharp & Dohme LLC

View on ClinicalTrials.gov

Summary

Researchers are looking for new treatments for HIV-1 (human immunodeficiency virus type 1) that are safe, well-tolerated, and can be taken less often. HIV-1 is the most common type of HIV, which is a virus that attacks cells of the immune system. Ulonivirine (MK-8507) is a study medicine designed to treat HIV-1 The goal of this study is to learn if ulonivirine does not increase the QT interval (a measure of heart rhythm on an electrocardiogram) above a certain amount. Researchers also want to learn what happens to the amount of ulonivirine in a healthy person's body over time.

Official title: A Double-Blind, Placebo-Controlled Trial to Evaluate the Effect of MK-8507 on the QTc Interval in Healthy Adult Participants

Key Details

Gender

All

Age Range

18 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

62

Start Date

2026-01-22

Completion Date

2026-04-09

Last Updated

2026-03-03

Healthy Volunteers

Yes

Conditions

Interventions

DRUG

Ulonivirine

Oral tablet

DRUG

Moxifloxacin

Oral tablet

DRUG

Ulonivirine Placebo

Oral tablet

DRUG

Moxifloxacin Placebo

Oral tablet

Locations (1)

ICON Early Phase Services (0001)

San Antonio, Texas, United States