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Comparison of Early Caffeine Administration Vs Supportive Therapy in Preventing Acute Kidney Injury
Sponsor: Muhammad Aamir Latif
Summary
Recent observational data point towards a reduced incidence of acute kidney injury (AKI) with early caffeine use, but high-quality randomized controlled trials comparing early caffeine initiation to supportive therapy alone are lacking. This study aims to fill this critical gap by comparing the efficacy of early caffeine administration versus supportive therapy in preventing AKI in preterm neonates.
Official title: Comparative Efficacy of Early Caffeine Administration Versus Supportive Therapy in Preventing Acute Kidney Injury in Preterm Neonates
Key Details
Gender
All
Age Range
1 Hour - 6 Hours
Study Type
INTERVENTIONAL
Enrollment
236
Start Date
2025-10-01
Completion Date
2026-03-31
Last Updated
2025-12-26
Healthy Volunteers
No
Conditions
Interventions
Caffeine
Neonates will receive caffeine citrate (IV or enteral) in 20 mg/kg loading dose within 24 hours of life, followed by a 5 mg/kg/day maintenance dose.
Supportive care
Neonates will be given supportive care without caffeine.
Locations (1)
The Children's Hospital & The Institute of Child Health
Multan, Punjab Province, Pakistan