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RECRUITING
NCT07308132
PHASE1

A Study of JNJ-95566692 in Participants With Non-Hodgkin Lymphoid Malignancies

Sponsor: Janssen Research & Development, LLC

View on ClinicalTrials.gov

Summary

The purpose of this study is to determine the putative recommended Phase 2 doses (RP2Ds) and optimal dose schedule(s) for JNJ-95566692 as a single agent (Arm A) and in combination with JNJ-87801493 (Arm B) (Part 1: Dose Escalation) and to further characterize the safety and clinical activity of JNJ-95566692 as a single agent (Arm A) and in combination with JNJ-87801493 (Arm B) at the putative RP2D(s) (Part 2: Dose Expansion).

Official title: A Phase 1, First-in-Human Study of a Novel CD79bxCD20xCD3 Trispecific Antibody in B-Cell Non-Hodgkin Lymphoid Malignancies (NHLs)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

130

Start Date

2026-01-20

Completion Date

2028-08-31

Last Updated

2026-03-13

Healthy Volunteers

No

Interventions

DRUG

JNJ-95566692

JNJ-95566692 will be administered subcutaneously.

DRUG

JNJ-87801493

JNJ-87801493 will be administered subcutaneously.

Locations (7)

Peter MacCallum Cancer Centre

Melbourne, Australia

Macquarie University Hospital

North Ryde, Australia

Scientia Clinical Research

Randwick, Australia

UZ Antwerpen

Edegem, Belgium

SBU Ankara Dr. Abdurrahman Yurtaslan Onkoloji Egitim ve Arastirma Hastanesi Faz 1 Merkezi

Ankara, Turkey (Türkiye)

Ankara Universitesi Hastaneleri Tibbi Farmakoloji Anabilim Dali Faz 1 Klinik Arastirma Merkezi

Ankara, Turkey (Türkiye)

Koc Universitesi Hastanesi Faz 1 Klinik Arastirma Merkezi

Istanbul, Turkey (Türkiye)