Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study of JNJ-95566692 in Participants With Non-Hodgkin Lymphoid Malignancies
Sponsor: Janssen Research & Development, LLC
Summary
The purpose of this study is to determine the putative recommended Phase 2 doses (RP2Ds) and optimal dose schedule(s) for JNJ-95566692 as a single agent (Arm A) and in combination with JNJ-87801493 (Arm B) and for JNJ-95566692 with or without JNJ-87801493 with various standard of care (SOC) regimens (Arms C-G) in Part 1: Dose Escalation part of the study. Part 2: Dose Expansion part of the study will further characterize the safety.
Official title: A Phase 1, First-in-Human Study of a Novel CD79bxCD20xCD3 Trispecific Antibody in B-Cell Non-Hodgkin Lymphoid Malignancies (NHLs)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
340
Start Date
2026-01-20
Completion Date
2029-10-31
Last Updated
2026-09-10
Healthy Volunteers
No
Conditions
Interventions
JNJ-95566692
JNJ-95566692 will be administered subcutaneously.
JNJ-87801493
JNJ-87801493 will be administered subcutaneously.
loncastuximab tesirine
Loncastuximab tesirine will be administered intervenously.
Lenalidomide
Lenalidomide will be administered orally.
Rituximab
Rituximab will be administered intravenously and may be administered subcutaneously after the first administration.
Gemcitabine
Gemcitabine will be administered intravenously.
Oxaliplatin
Oxaliplatin will be administered intravenously.
Cyclophosphamide
Cyclophosphamide will be administered intravenously.
Doxorubicin
Doxorubicin will be administered intravenously.
Vincristine
Vincristine will be administered intravenously.
Prednisone
Prednisone will be administered orally.
Polatuzumab vedotin
Polatuzumab vedotin will be administered intravenously.
Locations (19)
Monash Medical Centre
Clayton, Australia
Peter MacCallum Cancer Centre
Melbourne, Australia
Macquarie University Hospital
North Ryde, Australia
Scientia Clinical Research
Randwick, Australia
UZ Antwerpen
Edegem, Belgium
Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman
Liège, Belgium
Hopital Claude Huriez
Lille, France
CHU Pitie Salpetriere
Paris, France
CHU Lyon Sud
Pierre-Bénite, France
Institut Universitaire du Cancer Toulouse Oncopole
Toulouse, France
Hosp Univ Vall D Hebron
Barcelona, Spain
Hosp. Clinic de Barcelona
Barcelona, Spain
Hosp Univ Fund Jimenez Diaz
Madrid, Spain
Hosp. Univ. 12 de Octubre
Madrid, Spain
Hosp Univ Hm Sanchinarro
Madrid, Spain
SBU Ankara Dr. Abdurrahman Yurtaslan Onkoloji Egitim ve Arastirma Hastanesi Faz 1 Merkezi
Ankara, Turkey (Türkiye)
Ankara Universitesi Hastaneleri Tibbi Farmakoloji Anabilim Dali Faz 1 Klinik Arastirma Merkezi
Ankara, Turkey (Türkiye)
Memorial Antalya Hastanesi Faz 1 Klinik Arastirma Merkezi
Antalya, Turkey (Türkiye)
Koc Universitesi Hastanesi Faz 1 Klinik Arastirma Merkezi
Istanbul, Turkey (Türkiye)