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A Study of JNJ-95566692 in Participants With Non-Hodgkin Lymphoid Malignancies
Sponsor: Janssen Research & Development, LLC
Summary
The purpose of this study is to determine the putative recommended Phase 2 doses (RP2Ds) and optimal dose schedule(s) for JNJ-95566692 as a single agent (Arm A) and in combination with JNJ-87801493 (Arm B) (Part 1: Dose Escalation) and to further characterize the safety and clinical activity of JNJ-95566692 as a single agent (Arm A) and in combination with JNJ-87801493 (Arm B) at the putative RP2D(s) (Part 2: Dose Expansion).
Official title: A Phase 1, First-in-Human Study of a Novel CD79bxCD20xCD3 Trispecific Antibody in B-Cell Non-Hodgkin Lymphoid Malignancies (NHLs)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
130
Start Date
2026-01-20
Completion Date
2028-08-31
Last Updated
2026-03-13
Healthy Volunteers
No
Conditions
Interventions
JNJ-95566692
JNJ-95566692 will be administered subcutaneously.
JNJ-87801493
JNJ-87801493 will be administered subcutaneously.
Locations (7)
Peter MacCallum Cancer Centre
Melbourne, Australia
Macquarie University Hospital
North Ryde, Australia
Scientia Clinical Research
Randwick, Australia
UZ Antwerpen
Edegem, Belgium
SBU Ankara Dr. Abdurrahman Yurtaslan Onkoloji Egitim ve Arastirma Hastanesi Faz 1 Merkezi
Ankara, Turkey (Türkiye)
Ankara Universitesi Hastaneleri Tibbi Farmakoloji Anabilim Dali Faz 1 Klinik Arastirma Merkezi
Ankara, Turkey (Türkiye)
Koc Universitesi Hastanesi Faz 1 Klinik Arastirma Merkezi
Istanbul, Turkey (Türkiye)