Clinical Research Directory

Inclusion Criteria: 1. Adults aged ≥ 18 years. 2. Clinical diagnosis of a bacterial corneal ulcer based on slit-lamp examination. 3. Ulcer severity classified as: * Mild: Diameter ≤ 3 mm AND stromal depth ≤ 1/3 thickness. * Moderate: Diameter \>3-6 mm and/or stromal depth \> 1/3-2/3. * Severe: Diameter \>6 mm and/or stromal depth \>2/3. 4. Completed microbiologic work-up including ≥ 1 of: * Corneal culture, or * PCR testing. 5. Received ≥ 48-96 hours of empiric topical antibiotic therapy prior to randomization (fluoroquinolone monotherapy or fortified cefazolin/tobramycin based on standard of care). 6. Able and willing to provide informed consent and comply with study visits. Exclusion Criteria: 1. Clinical or laboratory evidence of: * Herpes simplex keratitis. * Acanthamoeba keratitis. * Fungal keratitis (positive smear, culture or PCR). 2. Corneal perforation or imminent perforation at presentation. 3. Current use of: * Topical corticosteroids in the study eye, or * Systemic corticosteroids during this ulcer episode. 4. History of steroid-responsive glaucoma or uncontrolled intraocular pressure (IOP).