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Effects of Isotretinoin on Smell
Sponsor: Uşak University
Summary
Isotretinoin is a common medicine used to treat moderate to severe acne. It often causes dryness of the skin and the inside of the nose. Because a normal sense of smell depends on a healthy nasal lining, this dryness may affect how well a person can smell. This study will examine whether isotretinoin treatment changes the sense of smell in adults with acne. Before starting isotretinoin, participants will complete a standardized smell test and two short questionnaires about nasal symptoms and quality of life (NOSE and SNOT-22). After at least 4 weeks of treatment, the same smell test and questionnaires will be repeated. By comparing results before and after treatment, the study will test the hypothesis that isotretinoin has a negative effect on olfactory function and may reduce patients' ability to smell.
Official title: Effects of Isotretinoin on Nasal Mucociliary Clearance and Olfactory Function
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
54
Start Date
2025-06-01
Completion Date
2026-06-01
Last Updated
2025-12-30
Healthy Volunteers
No
Conditions
Interventions
isotretinoin
Oral isotretinoin prescribed as standard-of-care treatment for acne vulgaris. The dosage, formulation, and duration of therapy will follow routine clinical practice and will be determined by the treating dermatologist based on the participant's clinical condition and body weight. Participants will typically receive daily oral isotretinoin for at least four weeks before the post-treatment assessments.
Locations (1)
Uşak University Faculty of Medicine
Uşak, Merkez, Turkey (Türkiye)