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Creatine and Perioperative Brain Health
Sponsor: Massachusetts General Hospital
Summary
The overall goal of this study is to evaluate the feasibility of perioperative oral creatine supplementation and to explore its effects on cognitive function and physiological responses to surgery in older adults. Creatine is commonly used to enhance athletic performance, but it can also have positive effects on the brain. Since surgery can alter thinking, memory, and attention patterns in some patients, we will assess whether creatine affects these changes in older adults undergoing surgery.
Official title: Creatine Intervention in Older Adults to Improve Perioperative Brain Health: a Randomized Controlled Trial (CREATE Trial)
Key Details
Gender
All
Age Range
60 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2026-09-01
Completion Date
2028-08-30
Last Updated
2026-08-10
Healthy Volunteers
Yes
Interventions
Creatine monohydrate
Participants will receive creatine supplementation before surgery
Placebo
Participants in the placebo group will receive an identical placebo before surgery