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Examining the Impact of Phytoestrogens Supplementation on the Gene Expression, and Premenstrual Syndrome in Primenopausal Women
Sponsor: University of Jordan
Summary
This randomized, double-blind, placebo-controlled clinical trial investigated the effects of flaxseed-derived phytoestrogen supplementation on selected gene-expression markers and premenstrual syndrome (PMS) severity among perimenopausal women aged 40-55 years in Jordan. Participants received either a flaxseed lignan extract providing 100 mg of lignans daily or a matched placebo for 12 weeks. Gene expression and PMS severity were assessed at baseline and at the end of the intervention to examine the potential effects of phytoestrogen supplementation on selected molecular markers and menstrual-related symptoms.
Official title: Examining the Impact of Phytoestrogens Supplementation on the Gene Expression and Premenstrual Syndrome in Perimenopausal Women Aged 40-55 in Jordan
Key Details
Gender
FEMALE
Age Range
40 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2025-11-01
Completion Date
2026-08-31
Last Updated
2026-09-04
Healthy Volunteers
Yes
Interventions
SDG lignans
SDG lignans phytoestrogen 100 mg SDG (Active Ingredient), taken orally once daily for 12 weeks
Placebo
Microcrystalline cellulose (Placebo), taken orally once daily for 12 weeks. The capsule is matched in size, color, and taste to the active SDG supplement.
Locations (1)
the university of Jordan
Amman, Amman Governorate, Jordan