Clinical Research Directory

Inclusion Criteria: 1. Age ≥ 70 years. 2. Multivessel coronary artery disease identified on coronary computed tomography angiography (CCTA), defined as ≥50% stenosis in at least two of the three major epicardial coronary arteries. 3. Scheduled to undergo invasive coronary angiography as part of standard clinical care. 4. Able to provide informed consent, or consent provided by a legally authorized representative. Exclusion Criteria: 1. Previous coronary revascularization, including percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). 2. Acute myocardial infarction at admission, according to electrocardiographic findings and elevated cardiac biomarkers consistent with acute MI. 3. Poor-quality CCTA images that prevent accurate assessment of coronary plaque characteristics or stenosis severity. 4. Refusal or inability to participate in the study or to provide informed consent.