Clinical Research Directory

A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia

Sponsor: Massachusetts General Hospital

Summary

In this study, the investigators will follow two small cohorts of pregnant women: a cohort of healthy women with uncomplicated pregnancies residing at high altitude, and a hospitalized cohort of symptomatic women with pregnancies complicated by obstetric conditions (e.g., preeclampsia), to characterize differences in cardiopulmonary adaptation and nitric oxide (NO) pathway expression at elevations \>3,500 m throughout pregnancy and into the postpartum period. The investigators aim to investigate right-sided cardiac impairment induced by chronic hypobaric hypoxemia, its effects on fetal growth, and the potential contribution of cardiovascular nitric oxide depletion to obstetric complications such as preeclampsia, pulmonary arterial hypertension, and right ventricular dysfunction.

Key Details

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