Clinical Research Directory

Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Availability and willingness to attend the Royal Derby Hospital site for a minimum of 8 exercise sessions and 2 assessment sessions across the study period. Exclusion Criteria: * BMI \<18 or \>35 kg/m2 * Known active cance * Known metabolic disease * Current known neurological or musculoskeletal conditions (e.g. epilepsy) * Active known cardiovascular, cerebrovascular or respiratory disease - e.g: * Uncontrolled hypertension (systolic BP \> 160 mmHg or diastolic BP \>100 mmhg) * Myocardial infarction within the last 6 months or unstable angina * Heart failure (New York Heart association Class III/IV) * Arrhythmia * Right to left cardiac shunt * Aneurysm of a named blood vessel * COPD * Pulmonary hypertension * Exercise-induced or brittle asthma * Previous stroke/transient ischaemic attack * Abnormal ECG results (at the discrepancy of the study doctor) * Patients who are unable to undergo CPET based on ATS/ACSS guidelines \^ * Pre-existing clotting disorder known to the participant or anticoagulant use * Family history of severe bleeding requiring medical intervention * Participation in a research study in the last 3 months involving invasive procedures or an inconvenience allowance (ALL UoN FMHS UREC approved studies) * Pregnant or breastfeeding