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Viability Assessment Using FMN Measured in Perfusate and Bile During Normothermic Machine Perfusion
Sponsor: The Cleveland Clinic
Summary
Discarded perfusate samples will be collected from donors after circulatory death (DCD) or donors after brain death (DBD) organs during the machine perfusion period prior to transplantation by the study team. FMN will be measured as is standard of care for all machine perfusion liver transplant cases at Cleveland Clinic. Participating centers will be provided with sample collection and shipping instructions to ensure sample preservation in accordance with IATA guidelines. Samples from outside sites will not be stored for future research and will be discarded once analysis is completed. After the collection of the samples from machine perfusion, the transplant procedure will continue according to standard process.
Official title: Viability Assessment Using Flavin Mononucleotide (FMN) Measured in Perfusate and Bile During Normothermic Machine Perfusion: an International, Multi-center Validation Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
850
Start Date
2025-12-29
Completion Date
2028-12-31
Last Updated
2026-01-07
Healthy Volunteers
No
Conditions
Locations (1)
Cleveland Clinic Foundation
Cleveland, Ohio, United States