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The Effect of Oral Iron Supplements on Insulin and Glucose Metabolism in Overweight and Obese Women
Sponsor: Nicole Stoffel
Summary
The study will be a randomized, double-blind, 17-day metabolic intervention trial including 14 days of high-dose or low-dose iron supplementation. A total of 70 overweight or obese (OW/OB) women will be enrolled. Participants will be individually randomized into either the high-iron or low-iron group. Women in the low-iron group will receive 15 mg of iron as ferrous fumarate daily for 14 days, while women in the high-iron group will receive 195 mg of iron as ferrous sulfate daily for 14 days. The study consists of three visits in total. On Day 0, a fasting blood sample will be collected and an OGTT will be performed, with additional blood samples collected at 1 hour and 2 hours post-OGTT. The OGTT will be repeated on Day 14, after 14 days of oral iron supplementation, and again on Day 17, four days after oral iron supplementation has been stopped
Key Details
Gender
FEMALE
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2025-12-23
Completion Date
2026-06-30
Last Updated
2026-01-02
Healthy Volunteers
No
Conditions
Interventions
195 mg iron daily
3 x 65 mg iron as ferrous sulfate
15 mg iron daily
3 x 5 mg iron as ferrous sulfate
Locations (1)
American University of Beirut
Beirut, Lebanon