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Maximizing the Benefits of Iron in Ready-to-Use Therapeutic Foods for Malnourished Children in Kenya
Sponsor: ETH Zurich
Summary
Reports from the Kenya Red Cross Society (KRCS) in Kwale County, southern Kenya, indicate a limited impact of Ready-to-Use Therapeutic Foods (RUTFs) on malnutrition or anemia. The current RUTF formulation may have an excessively high iron content. In severely acutely malnourished (SAM) children, iron cannot be properly absorbed, leading to life-threatening diarrhea. The overall aim of this project is to develop an improved RUTF treatment that addresses acute malnutrition and anemia in children, ensuring both safety and efficacy. Specifically, to assess the impact of malnutrition on fractional iron absorption (FIA) from RUTFs in children, by comparing healthy children to those with acute malnutrition and by tracking changes in FIA in malnourished children over the course of treatment.
Official title: Maximizing the Benefits of Iron in Ready-to-use Therapeutic Foods for Malnourished Children in Kenya
Key Details
Gender
All
Age Range
12 Months - 54 Months
Study Type
INTERVENTIONAL
Enrollment
68
Start Date
2025-12-23
Completion Date
2026-06-30
Last Updated
2026-01-02
Healthy Volunteers
Yes
Conditions
Interventions
Iron absorption from RUTF on Day 0
RUFT with 57Fe
Treatment with RUTF for 80 days
Daily RUTF intake
Iron absorption from RUTF on Day 20
RUFT with 57Fe
Iron absorption from RUTF on Day 40
RUFT with 57Fe
Iron absorption from RUTF on Day 60
RUFT with 57Fe
Locations (2)
ETH/Oxford/JKUAT research facility
Msambweni, Kwale County, Kenya
ETH Zurich, Laboratory of Clinical Biopharmacy, Zurich, 8092
Zurich, Switzerland