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RECRUITING
NCT07315295
NA

Maximizing the Benefits of Iron in Ready-to-Use Therapeutic Foods for Malnourished Children in Kenya

Sponsor: ETH Zurich

View on ClinicalTrials.gov

Summary

Reports from the Kenya Red Cross Society (KRCS) in Kwale County, southern Kenya, indicate a limited impact of Ready-to-Use Therapeutic Foods (RUTFs) on malnutrition or anemia. The current RUTF formulation may have an excessively high iron content. In severely acutely malnourished (SAM) children, iron cannot be properly absorbed, leading to life-threatening diarrhea. The overall aim of this project is to develop an improved RUTF treatment that addresses acute malnutrition and anemia in children, ensuring both safety and efficacy. Specifically, to assess the impact of malnutrition on fractional iron absorption (FIA) from RUTFs in children, by comparing healthy children to those with acute malnutrition and by tracking changes in FIA in malnourished children over the course of treatment.

Official title: Maximizing the Benefits of Iron in Ready-to-use Therapeutic Foods for Malnourished Children in Kenya

Key Details

Gender

All

Age Range

12 Months - 54 Months

Study Type

INTERVENTIONAL

Enrollment

68

Start Date

2025-12-23

Completion Date

2026-06-30

Last Updated

2026-01-02

Healthy Volunteers

Yes

Interventions

OTHER

Iron absorption from RUTF on Day 0

RUFT with 57Fe

DIETARY_SUPPLEMENT

Treatment with RUTF for 80 days

Daily RUTF intake

OTHER

Iron absorption from RUTF on Day 20

RUFT with 57Fe

OTHER

Iron absorption from RUTF on Day 40

RUFT with 57Fe

OTHER

Iron absorption from RUTF on Day 60

RUFT with 57Fe

Locations (2)

ETH/Oxford/JKUAT research facility

Msambweni, Kwale County, Kenya

ETH Zurich, Laboratory of Clinical Biopharmacy, Zurich, 8092

Zurich, Switzerland