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RECRUITING
NCT07316023
PHASE2

Antimicrobial Photodynamic Therapy With ICG-Loaded Nanoparticles for Periodontitis Management

Sponsor: Nada Mahmoud Soliman

View on ClinicalTrials.gov

Summary

To better understand and treat your gum disease, dentists now use a system that stages its severity and grades its speed, rather than using old labels. The recommended first step is almost always a deep cleaning, which is very effective. However, because some bacteria can hide from cleanings and antibiotics, researchers are exploring a promising light-based treatment. This method uses a safe, light-activated dye and a gentle laser to target and kill bacteria without leading to resistance. To make this treatment even stronger, scientists are testing a way to package the dye inside tiny, biodegradable "containers" that deliver it directly to the germs. The goal of this research is to see if this advanced delivery method works better than the dye alone, hoping to provide a more powerful, non-surgical option to fight gum disease and protect your teeth."

Official title: Efficacy of Antimicrobial Photodynamic Therapy Using Polymeric Nanoparticles Loaded With Indocyanine Green in Management of Periodontitis.(A Randomized Controlled Clinical Trial Study With Microbiological Analysis )

Key Details

Gender

All

Age Range

36 Years - 50 Years

Study Type

INTERVENTIONAL

Enrollment

27

Start Date

2026-01-15

Completion Date

2026-08-30

Last Updated

2026-01-05

Healthy Volunteers

No

Interventions

DRUG

Non- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded nanoparticles

Supragingival scaling and subgingival debridement followed by placement of ICG-loaded nanoparticles activated by diode laser for antibacterial photodynamic therapy to effectively target and eliminate pathogenic bacteria.

DRUG

Non- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded macroparticles

supragingival scaling and subgingival debridement followed by ICG-loaded macroparticles activated by diode laser for antibacterial photodynamic therapy to effectively target and eliminate pathogenic bacteria.

OTHER

Non- surgical periodontal therapy only

supragingival scaling and subgingival debridement only

Locations (1)

Faculty of Dentistry , Ainshams University

Cairo, Egypt