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Antimicrobial Photodynamic Therapy With ICG-Loaded Nanoparticles for Periodontitis Management
Sponsor: Nada Mahmoud Soliman
Summary
To better understand and treat your gum disease, dentists now use a system that stages its severity and grades its speed, rather than using old labels. The recommended first step is almost always a deep cleaning, which is very effective. However, because some bacteria can hide from cleanings and antibiotics, researchers are exploring a promising light-based treatment. This method uses a safe, light-activated dye and a gentle laser to target and kill bacteria without leading to resistance. To make this treatment even stronger, scientists are testing a way to package the dye inside tiny, biodegradable "containers" that deliver it directly to the germs. The goal of this research is to see if this advanced delivery method works better than the dye alone, hoping to provide a more powerful, non-surgical option to fight gum disease and protect your teeth."
Official title: Efficacy of Antimicrobial Photodynamic Therapy Using Polymeric Nanoparticles Loaded With Indocyanine Green in Management of Periodontitis.(A Randomized Controlled Clinical Trial Study With Microbiological Analysis )
Key Details
Gender
All
Age Range
36 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
27
Start Date
2026-01-15
Completion Date
2026-08-30
Last Updated
2026-01-05
Healthy Volunteers
No
Conditions
Interventions
Non- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded nanoparticles
Supragingival scaling and subgingival debridement followed by placement of ICG-loaded nanoparticles activated by diode laser for antibacterial photodynamic therapy to effectively target and eliminate pathogenic bacteria.
Non- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded macroparticles
supragingival scaling and subgingival debridement followed by ICG-loaded macroparticles activated by diode laser for antibacterial photodynamic therapy to effectively target and eliminate pathogenic bacteria.
Non- surgical periodontal therapy only
supragingival scaling and subgingival debridement only
Locations (1)
Faculty of Dentistry , Ainshams University
Cairo, Egypt