Clinical Research Directory

Inclusion Criteria: Probands: 1. 18 years of age or older 2. Speaks and reads English or Spanish 3. Resides in the United States 4. Has a pathogenic or suspected pathogenic variant in BRCA1, BRCA2, MLH1, MSH2/EPCAM, MSH6, or PMS2\* 5. Has access to the internet or phone and can send and receive email and/or text messages at a US telephone number. 6. Attests to have at least one at-risk relative who meets inclusion criteria for first-degree relative \*For cancer patients who are unaware of their mutation status, we will share existing local and national genetics resources, like those provided in the usual care family letter. At-Risk Relatives (ARR): 1. 18 years of age or older 2. Speaks and reads English or Spanish 3. Resides in the United States 4. Has a first or second degree relative who has a deleterious/suspected deleterious HBOC or LS variant present 5. Has access to internet or phone and can send and receive email and/or text messages at a US telephone number Exclusion Criteria: Probands: 1. Has no eligible at-risk relatives (ARRs) or is unable/unwilling to provide their contact information 2. Has negative germline genetic testing or only variant of uncertain significance 3. Unwilling or unable to provide consent At-Risk Relatives (ARR): 1. Unwilling or unable to provide consent 2. Reports no known HBOC or LS variant within the family 3. Has already been tested for the variant identified in the proband 4. Already listed as an ARR for another proband