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RECRUITING
NCT07318480
NA

Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder

Sponsor: Icahn School of Medicine at Mount Sinai

View on ClinicalTrials.gov

Summary

The researchers will test whether cognitively enhanced transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex can reduce craving in inpatients with cocaine use disorder. Neuroimaging before and after stimulation will establish the neural correlates of recovery and allow predictions of outcomes, which will be assessed throughout the study and one month after its completion. Results could pave the way towards development of a new self-administered intervention to reduce craving when it is needed the most, enhancing recovery real-time and in the natural environment in people with cocaine addiction as generalizable to other drugs of abuse and other disorders of self-control.

Official title: Cognitively-enhanced tDCS of the Dorsolateral Prefrontal Cortex to Reduce Craving in Cocaine Addiction

Key Details

Gender

All

Age Range

18 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

120

Start Date

2026-02-25

Completion Date

2030-02

Last Updated

2026-03-03

Healthy Volunteers

No

Interventions

DEVICE

Transcranial Direct Current Stimulator (tDCS)

Participants will have two electrodes applied (one anode, one cathode) administering active (real) or sham (placebo, not real) tDCS stimulation of the dorsolateral prefrontal cortex. Stimulation will last 20 minutes per day, three days per week, for 5 weeks

BEHAVIORAL

Cognitive Reappraisal Training

Cognitive reappraisal of drug cues during stimulation sessions

Locations (1)

Icahn School of Medicine at Mount Sinai

New York, New York, United States