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Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder
Sponsor: Icahn School of Medicine at Mount Sinai
Summary
The researchers will test whether cognitively enhanced transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex can reduce craving in inpatients with cocaine use disorder. Neuroimaging before and after stimulation will establish the neural correlates of recovery and allow predictions of outcomes, which will be assessed throughout the study and one month after its completion. Results could pave the way towards development of a new self-administered intervention to reduce craving when it is needed the most, enhancing recovery real-time and in the natural environment in people with cocaine addiction as generalizable to other drugs of abuse and other disorders of self-control.
Official title: Cognitively-enhanced tDCS of the Dorsolateral Prefrontal Cortex to Reduce Craving in Cocaine Addiction
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2026-02-25
Completion Date
2030-02
Last Updated
2026-03-03
Healthy Volunteers
No
Interventions
Transcranial Direct Current Stimulator (tDCS)
Participants will have two electrodes applied (one anode, one cathode) administering active (real) or sham (placebo, not real) tDCS stimulation of the dorsolateral prefrontal cortex. Stimulation will last 20 minutes per day, three days per week, for 5 weeks
Cognitive Reappraisal Training
Cognitive reappraisal of drug cues during stimulation sessions
Locations (1)
Icahn School of Medicine at Mount Sinai
New York, New York, United States