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A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)
Sponsor: Merck Sharp & Dohme LLC
Summary
Researchers are looking for new ways to treat ovarian cancer (OC). Current treatment for OC may start with surgery to remove as much of the cancer as possible. After surgery, people may receive chemotherapy. After chemotherapy, standard care options may include: * Maintenance treatment, which is used after another therapy to keep the cancer from growing, spreading, or coming back. Bevacizumab is a targeted therapy used as standard maintenance treatment. Targeted therapy works to control how specific types of cancer cells grow and spread. * Observation, which is watching to see if cancer grows or worsens The study medicine, sacituzumab tirumotecan (also called sac-TMT), is a targeted therapy. The goal of this study is to learn if people who receive sac-TMT maintenance treatment with or without bevacizumab live longer without the cancer getting worse than people who receive standard care.
Official title: A Phase 3, Randomized, Open-label, Multicenter Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) Maintenance Treatment With or Without Bevacizumab Versus Standard of Care in Participants With Newly Diagnosed Advanced Non-HRD Positive Ovarian Cancer Following First-line Platinum-based Chemotherapy (TroFuse-021/ENGOTov85/GOG-3102)
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
900
Start Date
2026-02-16
Completion Date
2033-02-25
Last Updated
2026-07-06
Healthy Volunteers
No
Conditions
Interventions
Sacituzumab tirumotecan
Administered via intravenous (IV) infusion at a dose of 4mg/kg
Bevacizumab
Administered via IV infusion at a dose of 15mg/kg
Rescue Medications
Participants must receive prophylactic steroid mouthwash (dexamethasone or equivalent). It is recommended that participants receive the following rescue medications prior to sac-TMT infusion, per approved product label: histamine-1 receptor antagonist, histamine-2 receptor antagonist, acetaminophen or equivalent, and dexamethasone or equivalent.
Locations (118)
Mount Sinai Cancer Center ( Site 0029)
Miami Beach, Florida, United States
Orlando Health Winnie Palmer Hospital for Women and Babies ( Site 0085)
Orlando, Florida, United States
Winship Cancer Institute of Emory University ( Site 0037)
Atlanta, Georgia, United States
Parkview Research Center at Parkview Regional Medical Center ( Site 0055)
Fort Wayne, Indiana, United States
Women's Cancer Care ( Site 0018)
Covington, Louisiana, United States
Nebraska Methodist Hospital ( Site 0004)
Omaha, Nebraska, United States
University Of Nebraska Medical Center ( Site 0035)
Omaha, Nebraska, United States
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0007)
Tulsa, Oklahoma, United States
Women & Infants Hospital ( Site 0001)
Providence, Rhode Island, United States
West Cancer Center and Research Institute ( Site 0013)
Germantown, Tennessee, United States
University of Tennessee Medical Center ( Site 0087)
Knoxville, Tennessee, United States
Hospital Aleman ( Site 2903)
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Instituto Alexander Fleming ( Site 2902)
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Instituto de Investigaciones Clinicas Mar del Plata ( Site 2901)
Mar del Plata, Buenos Aires, Argentina
Fundación Respirar ( Site 2912)
Buenos Aires, Buenos Aires F.D., Argentina
Sanatorio Parque - Oncología ( Site 2911)
Rosario, Santa Fe Province, Argentina
Instituto de Oncologia de Rosario ( Site 2909)
Rosario, Santa Fe Province, Argentina
Hospital Britanico de Buenos Aires ( Site 2905)
CABA, Argentina
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 2907)
La Rioja, Argentina
Gallipoli Medical Research Ltd ( Site 0204)
Brisbane, Queensland, Australia
Epworth Freemasons ( Site 0207)
East Melbourne, Victoria, Australia
Medizinische Universitat Wien ( Site 0102)
Vienna, State of Vienna, Austria
Medizinische Universitaet Innsbruck-Univ.-Klinik f. Gynäkologie und Geburtshilfe ( Site 0101)
Innsbruck, Tyrol, Austria
Grand Hopital de Charleroi ( Site 0303)
Charleroi, Hainaut, Belgium
AZ Maria Middelares ( Site 0302)
Ghent, Oost-Vlaanderen, Belgium
UZ Leuven ( Site 0301)
Leuven, Vlaams-Brabant, Belgium
Liga Norte Riograndense Contra o Cancer ( Site 0417)
Natal, Rio Grande do Norte, Brazil
Hospital São Lucas da PUCRS ( Site 0415)
Porto Alegre, Rio Grande do Sul, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0414)
São José do Rio Preto, São Paulo, Brazil
CIUSSS - Saguenay-Lac-Saint-Jean ( Site 0519)
Chicoutimi, Quebec, Canada
McGill University Health Centre ( Site 0516)
Montreal, Quebec, Canada
Fundacion Colombiana de Cancerología Clinica Vida ( Site 0803)
Medellín, Antioquia, Colombia
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0801)
Bogotá, Bogota D.C., Colombia
Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0802)
Valledupar, Cesar Department, Colombia
Instituto Nacional De Cancerologia ( Site 0808)
Bogota, Cundinamarca, Colombia
Oncólogos del Occidente S.A.S. ( Site 0806)
Pereira, Risaralda Department, Colombia
Fakultni Nemocnice Brno Bohunice ( Site 3304)
Brno, Brno-mesto, Czechia
Fakultni nemocnice Ostrava-Gynekologicko-porodnicka klinika ( Site 3303)
Ostrava-Poruba, Ostrava Mesto, Czechia
Fakultni nemocnice Kralovske Vinohrady ( Site 3306)
Prague, Czechia
Vseobecna fakultni nemocnice v Praze ( Site 3305)
Prague, Czechia
Fakultni nemocnice motol ( Site 3302)
Prague, Czechia
Herlev Hospital ( Site 0902)
Herlev, Capital Region, Denmark
Aalborg Universitetshospital ( Site 0901)
Aalborg, North Denmark, Denmark
Aarhus Universitetshospital, Skejby ( Site 0903)
Aarhus, North Denmark, Denmark
Odense Universitets Hospital ( Site 0904)
Odense, Region Syddanmark, Denmark
Oulun yliopistollinen sairaala ( Site 1003)
Oulu, North Ostrobothnia, Finland
Kuopion Yliopistollinen Sairaala ( Site 1004)
Kuopio, Northern Savonia, Finland
Tampereen yliopistollinen sairaala ( Site 1002)
Tampere, Pirkanmaa, Finland
Turku University Hospital-Department of Obstetrics and Gynecology ( Site 1001)
Turku, Southwest Finland, Finland
CENTRE LEON BERARD ( Site 1101)
Lyon, Auvergne-Rhône-Alpes, France
Hopitaux Universitaires de Strasbourg ( Site 1109)
Strasbourg, Bas-Rhin, France
Hôpital Privé Des Côtes d'Armor ( Site 1102)
Plérin, Cotes-d Armor, France
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau ( Site 1105)
Tours, Indre-et-Loire, France
Centre Oscar Lambret ( Site 1106)
Lille, Nord, France
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 1113)
Clermont-Ferrand, Puy-de-Dome, France
Alexandra General Hospital of Athens ( Site 0703)
Athens, Attica, Greece
Agios Loukas Clinic ( Site 0702)
Thessaloniki, Greece
Bacs-Kiskun Varmegyei Oktatokorhaz-Onkoradiologiai Kozpont ( Site 3910)
Kecskemét, Bács-Kiskun county, Hungary
Petz Aladar Egyetemi Oktato Korhaz-Onkológiai Osztály ( Site 3911)
Győr, Győr-Moson-Sopron, Hungary
Országos Onkológiai Intézet-Ngyógyászat ( Site 3913)
Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont-Szülészeti és Nőgyógyászati Klinika ( Site 3912)
Debrecen, Hungary
Rambam Health Care Campus ( Site 1422)
Haifa, Israel
Edith Wolfson Medical Center ( Site 1423)
Holon, Israel
Sheba Medical Center ( Site 1421)
Ramat Gan, Israel
Azienda Ospedaliera Spedali Civili di Brescia ( Site 1501)
Brescia, Italy
Istituto Nazionale dei Tumori ( Site 1504)
Milan, Italy
Istituto Europeo di Oncologia ( Site 1503)
Milan, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1510)
Roma, Italy
Gunma Prefectural Cancer Center ( Site 1605)
Ōta, Gunma, Japan
Hokkaido University Hospital ( Site 1609)
Sapporo, Hokkaido, Japan
Hyogo Cancer Center ( Site 1620)
Akashi, Hyōgo, Japan
Iwate Medical University Hospital ( Site 1610)
Shiwa-gun, Iwate, Japan
Saitama Medical University International Medical Center ( Site 1607)
Hidaka, Saitama, Japan
Cancer Institute Hospital of JFCR ( Site 1614)
Koto, Tokyo, Japan
Keio University Hospital ( Site 1611)
Shinjyuku, Tokyo, Japan
Kagoshima City Hospital ( Site 1613)
Kagoshima, Japan
Niigata Cancer Center Hospital ( Site 1608)
Niigata, Japan
Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 1604)
Osaka, Japan
Stavanger Universitetssjukehus ( Site 2002)
Stavanger, Rogaland, Norway
Sorlandet Sykehus Kristiansand ( Site 2003)
Kristiansand, Vest-Agder, Norway
Oslo University Hospital ( Site 2001)
Oslo, Norway
Uniwersytecki Szpital Kliniczny w Poznaniu-Oddzial Ginekologii Onkologicznej ( Site 2106)
Poznan, Greater Poland Voivodeship, Poland
Wielkopolskie Centrum Onkologii im. Marii Skłodowskiej-Curie ( Site 2105)
Poznan, Greater Poland Voivodeship, Poland
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2102)
Siedlce, Masovian Voivodeship, Poland
Bialostockie Centrum Onkologii ( Site 2104)
Bialystok, Podlaskie Voivodeship, Poland
Uniwersytecki Szpital Kliniczny nr2 PUM w Szczecinie ( Site 2103)
Szczecin, West Pomeranian Voivodeship, Poland
Severance Hospital ( Site 2302)
Seodaemun-Gu, Seoul, South Korea
Keimyung University Dongsan Hospital ( Site 2304)
Daegu, Taegu-Kwangyokshi, South Korea
Seoul National University Hospital ( Site 2301)
Seoul, South Korea
Asan Medical Center ( Site 2305)
Seoul, South Korea
Samsung Medical Center ( Site 2303)
Seoul, South Korea
Institut Català d'Oncologia (ICO) - Girona ( Site 2402)
Girona, Gerona, Spain
Complejo Hospitalario Universitario A Coruna ( Site 2412)
A Coruña, La Coruna, Spain
Clinica Universidad de Navarra ( Site 2407)
Madrid, Madrid, Comunidad de, Spain
Instituto Valenciano de Oncologia - IVO ( Site 2411)
Valencia, Valenciana, Comunitat, Spain
Hospital Vall D Hebron ( Site 2403)
Barcelona, Spain
Hospital Clinic I Provincial de Barcelona ( Site 2409)
Barcelona, Spain
ICO L Hospitalet ( Site 2408)
Barcelona, Spain
Hospital Universitario Reina Sofia ( Site 2406)
Córdoba, Spain
Hospital Ramon y Cajal ( Site 2405)
Madrid, Spain
Hospital Clinico San Carlos... ( Site 2410)
Madrid, Spain
Hospital Universitario La Paz-Oncología Médica ( Site 2404)
Madrid, Spain
Karolinska Universitetssjukhuset Solna ( Site 2502)
Stockholm, Stockholm County, Sweden
Inselspital Bern ( Site 3504)
Bern, Canton of Bern, Switzerland
Ospedale Regionale Bellinzona e Valli ( Site 3501)
Bellinzona, Canton Ticino, Switzerland
Kantonsspital Graubünden ( Site 3503)
Chur, Kanton Graubünden, Switzerland
Hôpitaux Universitaires de Genève (HUG) ( Site 3502)
Geneva, Switzerland
Taichung Veterans General Hospital ( Site 2603)
Taichung, Taiwan
National Cheng Kung University Hospital ( Site 2602)
Tainan, Taiwan
National Taiwan University Hospital ( Site 2601)
Taipei, Taiwan
Mackay Memorial Hospital ( Site 2604)
Taipei, Taiwan
Linkou Chang Gung Memorial Hospital ( Site 2605)
Taoyuan, Taiwan
Ramathibodi Hospital. ( Site 3402)
Bangkok, Bangkok, Thailand
Faculty of Medicine Siriraj Hospital ( Site 3401)
Bangkoknoi, Bangkok, Thailand
Faculty of Medicine - Khon Kaen University ( Site 3403)
Muang, Changwat Khon Kaen, Thailand
Addenbrookes Hospital ( Site 2802)
Cambridge, Cambridgeshire, United Kingdom
University Hospitals of Leicester NHS Trust ( Site 2805)
Leicester, Leicestershire, United Kingdom
The Christie NHS Foundation Trust ( Site 2804)
Manchester, United Kingdom