Clinical Research Directory

Inclusion Criteria: * Patients between 6 and 50 years old * weighting \> 20 kg * With focal seizures epilepsy * Requiring video-EEG recording in Epilepsy Monitoring Units (EMU) for the presurgical evaluation of a focal epilepsy, with planned ASM withdrawal in order to precipitate seizure occurrence * Able to take an oral therapy * Ability to record the patient \> 12 hours after the second seizure of the cluster * Having received informed information about the study and having signed a consent form to participate in the study. Written consent of both holders of parental authority for minor patients. Exclusion Criteria: * Hypersensitivity to PBN or to any of the excipients (Microcrystalline cellulose, Hypromellose, Sodium carboxymethylamidon, Colloidal anhydrous silica, Magnesium stearate) * Impaired renal function (creatinine clearance \< 50 mL/min) * Lithiasis diathesis * Treatment by the following drugs: penicillins cephalosporins, acetylsalicylic acid, methotrexate, acetaminophen, naproxen, indomethacin, ketoprofen, meclofenamate, lorazepam, rifampicin, acyclovir, ganciclovir and zidovudine, sulfonamide, dyprophylline * Acute gout attack * Hyperuricemia secondary to cancer chemotherapy, radiotherapy or myeloproliferative neoplasia * Primary hyperuricemia due to overproduction of uric acid. * Pregnant or breast-feeding woman * Patient benefiting from legal protection Secondary exclusion criteria (before randomization) : \- Patient not randomized: Not experiencing at least 2 seizures lasting less than 10 minutes in 6 hours or less period (defining a SC) during the video-EEG monitoring period OR having no seizure recorded before the cluster. Patients secondarily excluded will be excluded before randomization and will be replaced.