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Fibrin-Enhanced TIP Versus Grafted TIP Urethroplasty in Distal Hypospadias
Sponsor: National Children's Medical Center, Uzbekistan
Summary
Hypospadias is a common congenital condition in boys in which the opening of the urethra is located on the underside of the penis. Distal hypospadias is the most common form and is usually treated surgically using tubularized incised plate (TIP) urethroplasty. In boys with an unfavorable urethral plate, graft-augmented techniques (G-TIP) are often used; however, postoperative complications such as urethrocutaneous fistula and narrowing of the urethral opening (meatal stenosis) may still occur. Platelet-rich fibrin (PRF) is a biological material obtained from the patient's own blood that contains natural growth factors and may help improve tissue healing. This study aims to evaluate whether the use of PRF during surgery can reduce postoperative complications and improve surgical outcomes in children undergoing hypospadias repair.
Official title: A Multicenter Randomized Controlled Trial Comparing Fibrin-Enhanced Tubularized Incised Plate (F-TIP) and Grafted Tubularized Incised Plate (G-TIP) Urethroplasty in Distal Hypospadias With Unfavorable Urethral Plates
Key Details
Gender
MALE
Age Range
6 Months - 84 Months
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2026-01-05
Completion Date
2028-12-25
Last Updated
2026-01-30
Healthy Volunteers
No
Conditions
Interventions
Fibrin-Enhanced TIP Urethroplasty
Tubularized incised plate urethroplasty augmented with autologous platelet-rich fibrin membrane applied to the incised urethral plate prior to tubularization.
Grafted TIP Urethroplasty
Graft-augmented tubularized incised plate urethroplasty performed using standard surgical techniques for unfavorable urethral plates.
Locations (2)
Dr. Cipto Mangunkusumo Hospital
Jakarta, DKI Jakarta, Indonesia
National Children's Medical Center
Tashkent, Tashkent, Uzbekistan