Clinical Research Directory
Browse clinical research sites, groups, and studies.
The Role of Fluoride Varnish Application in Preventing White Spot Lesions During Clear Aligner Treatment: A Controlled Split-Mouth Study
Sponsor: Mansoura University
Summary
aim of study: is to compare the effect of the fluoride varnish application on the prevention of white spot lesions (WSLs) during clear aligner therapy Design Details: Each participant will have one side of the mouth assigned to the fluoride varnish intervention, while the contralateral side will serve as the control without fluoride varnish. Outcomes: Primary outcome: Incidence and Severity of White Spot Lesions Measured before and after six months using Laser fluorescence (DIAGNOdent) Secondary Outcome: Periodontal Ligament (PDL) Health using pocket Depth Index (PDI) Gingival Bleeding and Inflammation using bleeding on Probing Index (BOP)
Key Details
Gender
All
Age Range
16 Years - 24 Years
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2025-06-25
Completion Date
2027-02-01
Last Updated
2026-01-06
Healthy Volunteers
Yes
Conditions
Interventions
White spot lesion with fluoride varnish application
Application of fluoride varnish at the cervical third of labial surface or around the attachment if present
White spot lesion without fluoride varnish application
No fluoride varnish application at the cervical third of the labial surface or around the attachment if present
Locations (1)
Faculty of dentistry Mansoura University
Al Mansurah, Egypt