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A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis
Sponsor: Janssen Research & Development, LLC
Summary
The purpose of this study is to evaluate how well the study drug JNJ-88545223 works compared with a placebo (an inactive substance) in adults with active psoriatic arthritis (PsA). The study aims to see whether treatment with JNJ-88545223 can help reduce the signs and symptoms of PsA and improve joint and skin health.
Official title: A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of JNJ-88545223 For the Treatment of Participants With Active Psoriatic Arthritis
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
240
Start Date
2026-01-15
Completion Date
2027-08-02
Last Updated
2026-04-13
Healthy Volunteers
No
Conditions
Interventions
JNJ-88545223
JNJ-88545223 will be administered orally.
Placebo
Placebo will be administered orally.
Locations (40)
Unity Health-White County Medical Center
Searcy, Arkansas, United States
Newport Huntington Medical Group
Huntington Beach, California, United States
Rheumatology Center of San Diego
San Diego, California, United States
American Research, LLC
Cutler Bay, Florida, United States
Innovation Medical Research Center
Palmetto Bay, Florida, United States
Clinical Research of West Florida
Tampa, Florida, United States
Conquest Research
Winter Park, Florida, United States
Atlanta Research Center for Rheumatology
Marietta, Georgia, United States
Willow Rheumatology and Wellness PLLC
Willowbrook, Illinois, United States
Qualmedica Research
Evansville, Indiana, United States
Joint and Muscle Research Institute
Charlotte, North Carolina, United States
Paramount Medical Research & Consulting
Middleburg Heights, Ohio, United States
Clinical Research Philadelphia
Philadelphia, Pennsylvania, United States
Arthritis and Rheumatology Research Institute
Allen, Texas, United States
Peking University People's Hospital
Beijing, China
Peking University Third Hospital
Beijing, China
Changzhou No 2 Peoples Hospital
Changzhou, China
West China Hospital Sichuan University
Chengdu, China
The Second Affiliated Hospital of Zhejiang University
Hangzhou, China
Ningbo medical center lihuili hospital
Ningbo, China
Hamburger Rheuma Forschungszentrum II
Hamburg, Germany
CAIR Heidelberg
Heidelberg, Germany
Hautarztpraxis Mortazawi
Remscheid, Germany
Hautarztpraxis
Witten, Germany
Imamura General Hospital
Kagoshima, Japan
Hospital of the University of Occupational and Environmental Health
Kitakyushu-shi, Japan
Osaka Metropolitan University Hospital
Osaka, Japan
Sanuki Municipal Hospital
Sanuki, Japan
Tokito Clinic Rheumatology and Orthopaedic Surgery
Shimonoseki, Japan
Nzoz Osteo Medic
Bialystok, Poland
Centrum Kliniczno Badawcze
Elblag, Poland
Malopolskie Badania Kliniczne Sp z o o
Krakow, Poland
Pratia MCM Krakow
Krakow, Poland
Etyka Osrodek Badan Klinicznych Tomasz Pesta S K A
Olsztyn, Poland
MICS Centrum Medyczne Warszawa 1
Warsaw, Poland
Centrum Medyczne Reuma Park
Warsaw, Poland
FutureMeds Targowek
Warsaw, Poland
Hosp Univ A Coruna
A Coruña, Spain
Hosp. Virgen Macarena
Seville, Spain
Hosp. Virgen Del Rocio
Seville, Spain