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Antibiotic-coated Braided Suture Study
Sponsor: University of Miami
Summary
The purpose of this study is to evaluate whether the use of antibiotic-coated (triclosan) braided sutures is non-inferior or potentially superior to standard monofilament sutures in patients with prosthetic joint infections (PJIs) managed with the DAIR protocol. Several studies in various surgical specialties have demonstrated the effectiveness and non-inferiority of triclosan-coated braided sutures in infected surgical cases, and the study intends to transpose this idea to the management of prosthetic joint infections. Monofilament sutures are the present standard of care in any infected joint case due their lower surface area for bacterial harborization, though surgeons sacrifice mechanical integrity and comfortability with the closure in the process. By demonstrating the safety of antibiotic -coated braided sutures, surgeons will no longer have to make this compromise.
Official title: Evaluating the Use of Antibiotic-Coated Braided Sutures in Debridement, Antibiotic, and Implant Retention (DAIR) Procedures
Key Details
Gender
All
Age Range
18 Years - 89 Years
Study Type
INTERVENTIONAL
Enrollment
142
Start Date
2026-07-01
Completion Date
2027-12-31
Last Updated
2026-03-23
Healthy Volunteers
No
Conditions
Interventions
VICRYL™ Plus (Coated VICRYL™ Plus Antibacterial)
Synthetic, absorbable, braided suture coated with triclosan for antimicrobial protection. Used for fascial and skin closure. Offers high tensile strength and knot security
Polydioxanone (PDS™ II ) Sterile Synthetic Absorbable Surgical Suture-Monofilament
Absorbable, non-braided suture. Used for fascial and skin closure.
Locations (1)
University of Miami Health System
Miami, Florida, United States