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Development of Microbial Metabolism Gene Tests for Facilitating Precision Health and Preventive Medicine-Evaluation of TMAO Production in Human Body From High-carnitine Diet by Fecal Gbu Gene Testing
Sponsor: National Taiwan University Hospital
Summary
The risk of cardiovascular diseases from red meat consumption varies among individuals due to variations in gut microbiota. L-carnitine in red meat can be converted to Trimethylamine n-oxide (TMAO) in the body by certain bacteria. Not everyone experiences a significant increase in TMAO levels after consuming carnitine. Gut microbiota differences are observed between high and low TMAO producers. The presence of the γ-butyrobetaine utilization (gbu) gene in gut microbiota is linked to TMAO production. This clinical research aims to determine if the gbu gene can predict TMAO levels after intaking a large amount of red meat.
Official title: Evaluation of TMAO Production in Human Body From High-carnitine Diet by Fecal Gbu Gene Testing
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
65
Start Date
2026-01-15
Completion Date
2026-11-30
Last Updated
2026-01-08
Healthy Volunteers
Yes
Interventions
Beef
900 grams of lean beef
Locations (1)
National Taiwan University Hospital
Taipei, Taiwan