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ALDH2 Single Nucleotide Polymorphisms and Prognosis of Esophageal Cancer Patients
Sponsor: National Taiwan University Hospital
Summary
Alcohol consumption, smoking, and betel nut chewing have been proven to be closely associated with the risk of esophageal cancer (EC). Recent studies have shown that alcohol-related detoxification genes in the ALDH family influence individual susceptibility to esophageal cancer. Aldehyde dehydrogenase 2 (ALDH2) is one of the most important enzymes in the ALDH family, involved in the metabolism of alcohol, acetaldehyde, and environmental aldehydes in the human body. We hypothesize that functional variations in ALDH2 may have a significant impact on the survival of esophageal cancer patients. This study aims to investigate the correlation between ALDH2 gene polymorphism and the survival of esophageal cancer patients.
Key Details
Gender
MALE
Age Range
18 Years - 99 Years
Study Type
OBSERVATIONAL
Enrollment
700
Start Date
2025-12-08
Completion Date
2027-10-31
Last Updated
2026-01-07
Healthy Volunteers
No
Conditions
Locations (1)
National Taiwan University Hospital
Taipei, Taiwan