Clinical Research Directory

Inclusion Criteria: * Inclusion criteria for dry eye (participant must meet at least 1 of the inclusion criteria below): 1. Symptomatic for dry eye based on DEQ5 (\>6) and \[either TBUT less than 5 s or staining \>grade 1 in any zone of the cornea\] 2. Either use of diquasfosol, cyclosporine eyedrops or tacrolimus eyedrops for dry eye disease in the last 2 weeks (and previously started for more than 2 months), OR current and visible lower punctal plugs in at least one eye Inclusion criteria to fulfil all for controls (patients w/o dry eye): 1. DEQ5 \<=6. 2. Staining \< grade 1 in at least one corneal zone. 3. Not using diquasfosol, cyclosporine, tacrolimus in last 2 months. 4. No visible punctal plugs. Exclusion Criteria: * If there is another ocular condition which affects vision as much as cataract: active corneal stromal disease or scar or significant corneal endothelial disease * Known diagnosis of active thyroid dysfunction, Sjogren disease and rheumatoid arthritis * Intraocular surgery within the previous 6 months * Laser-assisted in situ keratomileusis or pterygium surgery within the previous 3 months * Central nervous system and hormonal drugs required within the last month and during the study * Active ocular infection, inflamed chalazion, or presence of pterygium * Glaucoma which requires topical anti-glaucoma medications * Any need to wear contact lens during the study * Having issues which make it difficult to follow up (eg., wheelchair, etc) * Pregnant and breast-feeding woman